Paul A. Broadhurst

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AIM Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized(More)
AIM Remote follow-up (FU) of implantable cardiac defibrillators (ICDs) allows for fewer in-office visits in combination with earlier detection of relevant findings. Its implementation requires investment and reorganization of care. Providers (physicians or hospitals) are unsure about the financial impact. The primary end-point of this randomized prospective(More)
A new, miniature cesium iodide/photodiode nuclear probe (the "Cardioscint") has been developed for continuous on-line measurement of left ventricular function and the ST-segment. Ejection fraction (EF) measurements in 77 patients were compared with gated equilibrium radionuclide ventriculograms. The probe was positioned over the left ventricle by first(More)
OBJECTIVE To see if strategy of ablating the tricuspid annulus-inferior vena cava isthmus (TV-IVC) is superior to electrical cardioversion to prevent recurrences in patients with coarse atrial fibrillation. DESIGN Prospective randomised controlled multicentre study. SETTING Four tertiary referral hospitals in the UK. PATIENTS 57 patients with(More)
OBJECTIVE To detect and characterise rapid temporal changes in the left ventricular response to exercise in patients with ischaemic heart disease and to relate these changes to the functional severity of coronary artery disease. BACKGROUND The gamma camera does not allow the detection of rapid changes in cardiac function during exercise radionuclide(More)
We report a case of supraventricular tachycardia associated with left bundle branch block due to a slowly conducting right sided accessory pathway. Preexcitation of the ventricles could not be demonstrated during sinus rhythm or incremental atrial pacing but its presence was confirmed during antedromic tachycardia with critically timed atrial extrastimuli.(More)
The 24-hour blood pressure (BP) profile of a new sustained-release preparation of nicardipine was assessed in 16 patients with essential hypertension (supine cuff diastolic BP>95 mmHg). Twenty-four hour ambulatory intraarterial BP monitoring (Oxford system) before treatment revealed a mean (SD) daytime BP of 174 (19) mmHg systolic and 105 (8) mmHg(More)
BACKGROUND : Takotsubo cardiomyopathy is an increasingly recognized acute heart failure syndrome precipitated by intense emotional stress. Although there is an apparent rapid and spontaneous recovery of left ventricular ejection fraction, the long-term clinical and functional consequences of takotsubo cardiomyopathy are ill-defined. METHODS : In an(More)
Three patients with acute infarction of the anterior wall of the heart underwent catheterisation of the coronary sinus. Samples were taken for estimation of activity of cardiac enzymes. A small gradient was demonstrated between the sinus and the venous blood, suggesting that the coronary sinus is the conduit by which these enzymes are liberated into the(More)