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CONTEXT Reference ranges are essential for partitioning testosterone levels into low or normal and making the diagnosis of androgen deficiency. We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men. METHODS TT was measured using liquid chromatography tandem mass spectrometry in nonobese(More)
PURPOSE Lower urinary tract symptom progression in community dwelling older men is not well described. MATERIALS AND METHODS We evaluated 5,697 participants in Osteoporotic Fractures in Men, a prospective cohort study of community dwelling men 65 years old or older. We characterized lower urinary tract symptoms using the American Urological Association(More)
CONTEXT Normocalcemic primary hyperparathyroidism is typically identified after referral to a specialty clinic. At diagnosis, patients demonstrate features seen in hypercalcemic primary hyperparathyroidism. Normocalcemic hypoparathyroidism has been discovered after hypocalcemia unmasked after bisphosphonate administration. OBJECTIVE We hypothesized that(More)
CONTEXT Little information exists about longitudinal changes in body composition and physical function in relation to sex hormone levels in older men. OBJECTIVE The aim of the study was to determine associations of testosterone, estradiol, and SHBG with changes in body composition and physical function. DESIGN AND SETTING We conducted a prospective(More)
OBJECTIVE Skeletal muscle adipose tissue (AT) infiltration (myosteatosis) increases with aging and may contribute to the development of Type 2 diabetes mellitus (T2DM). It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity. DESIGN AND METHODS The association between intermuscular AT(More)
OBJECTIVE To examine the association of cognitive function with sex steroid and sex hormone binding globulin (SHBG) levels among elderly men. DESIGN Prospective cohort study, The Osteoporotic Fractures in Men Study (MrOS), consisting of 5995 US community dwelling men of 65 years or older. PATIENTS One thousand six hundred and two men were chosen(More)
Low 25-hydroxyvitamin D (VitD), low sex hormones (SH), and high sex hormone binding globulin (SHBG) levels are common in older men. We tested the hypothesis that combinations of low VitD, low SH, and high SHBG would have a synergistic effect on bone mineral density (BMD), bone loss, and fracture risk in older men. Participants were a random subsample of(More)
BACKGROUND Data describing urinary health in elderly, community-dwelling prostate cancer (PCa) survivors are limited. OBJECTIVE To elucidate the prevalence of lower urinary tract symptoms, urinary bother, and incontinence in elderly PCa survivors compared with peers without PCa. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional analysis of 5990(More)
D istributed systems pose unique challenges for software developers. Reasoning about concurrent activities of system nodes and even understanding the system's communication topology can be difficult. A standard approach to gaining insight into system activity is to analyze system logs. Unfortunately, this can be a tedious and complex process. This article(More)