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INTRODUCTION Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent gastrointestinal conditions with accumulating evidence regarding an overlap between the two. Still, patients with NERD represent a very heterogeneous group and limited data on dyspeptic symptoms in various subgroups of NERD are available. AIM To evaluate the prevalence(More)
BACKGROUND AND AIMS Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. METHODS Twenty-five Italian healthy subjects (13(More)
BACKGROUND Limited data are available regarding the frequency of oesophageal motility and bolus transit abnormalities in subgroups of patients with gastro-oesophageal reflux disease (GERD). AIM To assess oesophageal motility and bolus transit in endoscopically defined GERD subgroups. METHODS Patients (N=755) with typical reflux symptoms underwent upper(More)
OBJECTIVES The main aim was to analyse the long-term therapeutic effects on systemic sclerosis (SSc) patients of treatment with either (i) iloprost alone or (ii) low-dose oral cyclosporin A (CyA) associated with iloprost. A secondary aim was to analyse interleukin-6 (IL-6) serum levels in SSc patients before and after 1 yr of treatment. METHODS A clinical(More)
BACKGROUND & AIMS Antibiotic resistance is a major issue in anti- Helicobacter pylori treatment. This study was aimed at assessing the efficacy of 2 therapies in patients with resistant H pylori infection. METHODS Patients who had failed 1 or more eradication regimens underwent upper gastrointestinal endoscopy and 2 antral and 2 corpus biopsy specimens(More)
To carry out a simultaneous comparison of the 24-h in vivo performance of antimony and glass electrodes and the findings of intermittent gastric aspiration, a triple-probe system with closely adjacent tips was positioned in the gastric corpus of 10 subjects representing different clinical and pharmacologic conditions. We showed that pH values measured with(More)
Four hundred and thirteen continuous, high-frequency-sampled gastric pH-metries were subdivided into six groups (normal subjects and patients with duodenal ulcer, gastric ulcer, chronic gastritis, prior cholecystectomy, or antisecretory treatment). The frequency distribution of those pH fluctuations that were greater than the quantitation error of(More)
BACKGROUND Gastro-esophageal reflux is considered a major culprit in the pathogenesis of Barrett's esophagus (BE). Still, there is controversy on the role of weakly acidic and weakly alkaline reflux in BE. To compare characteristics of reflux episodes patients with BE, erosive esophagitis (EE), and healthy volunteers (HV). METHODS One hundred consecutive(More)
The expression of gastric acidity as pH or antilog transformation of pH and the use of the mean or the median as the better summary variable are among the major problems concerning the assessment of antisecretory drugs' effects by means of continuous intraluminal pH monitoring. In this study, we reviewed data deriving from 23 normal subjects, 69(More)
Ambulatory pH monitoring is currently the best method for detection of gastro-oesophageal reflux. However, pH electrodes are able to measure only acid reflux, and therefore, non-acid reflux episodes, a potentially important cause of symptoms, are ignored by this technique. Multichannel intraluminal electrical impedance has recently been proposed as a novel(More)