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Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish.
The mechanisms underlying the early steps of thyroid development are largely unknown. In search for novel candidate genes implicated in thyroid function, we performed a gene expression analysis onExpand
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JAG1 Loss-Of-Function Variations as a Novel Predisposing Event in the Pathogenesis of Congenital Thyroid Defects.
CONTEXT The pathogenesis of congenital hypothyroidism (CH) is still largely unexplained. We previously reported that perturbations of the Notch pathway and knockdown of the ligand jagged1 cause aExpand
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  • Open Access
Increased risk for non-autoimmune hypothyroidism in young patients with congenital heart defects.
CONTEXT Newborns with congenital hypothyroidism (CH) have an increased risk for congenital heart defects (CHD) due to a common embryonic developmental program between thyroid gland and heart andExpand
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Absenceofprimaryhypothyroidismandgoiterin Slc26a4(-/-) micefedonalowiodinediet
Background: Mutations in the SLC26A4 gene, coding for the anion transporter pendrin, are responsible for Pendred syndrome, characterized by congenital sensorineural deafness and dyshormonogenicExpand