Patrizia Kraft

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BACKGROUND Endothelial injury is an important prognostic factor in acute respiratory distress syndrome (ARDS). Vascular endothelial growth factor (VEGF) plays a critical role in endothelial destruction and angiogenesis. Genetic variations of the VEGF gene have been associated with VEGF production. A study was undertaken to investigate the impact of VEGF(More)
Risk of multiple sclerosis (MS) decreases with increasing plasma levels of 25-hydroxyvitamin D [25(OH)D]. If this association reflected a protective effect of vitamin D, MS risk should be lower among individuals carrying genetic variants that predict high 25(OH)D levels. The aim of the study was to determine whether individuals with genotypes predicting(More)
Sirs: Embolic infarctions secondary to internal carotid artery (ICA) stenosis are usually located in the vascular territories of the anterior (ACA) and middle (MCA) cerebral arteries. In rare cases, if a fetal-type posterior circle of Willis is present, the territory of the posterior cerebral artery (PCA) may additionally be involved. Here we present a(More)
Antiarrhythmic drugs for treatment of atrial fibrillation in patients with heart failure are limited by proarrhythmia and low efficacy. Experimental studies indicate that the pure IKs blocking agents chromanol 293b and HMR 1556 prolong repolarization more markedly at fast than at slow heart rates and during β–adrenergic stimulation. These properties may(More)
The diagnostic problems are being discussed specifically in 9 patients with angiomyolipoma. Ultrasound and computerised tomography show clear results in tumours with a fatty structure, where angiography is a better method to show vascular elements. Where an inhomogeneous tissue structure is given, an exact diagnosis is only possible by using a combination(More)
Dogs with chronic AV block exposed to type-III antiarrhythmic agents develop polymorphic ventricular tachycardias (PVT). Controversy exists regarding PVT mechanism and underlying pathophysiology. In dogs with acute (n = 10, AAVB) or chronic AV block (n = 14, CAVB, 62 ± 5 days after AV-node ablation) 60 pins (12 mm long, 4 bipolar electrodes) were inserted(More)
Background: Endothelial injury is an important prognostic factor in acute respiratory distress syndrome (ARDS). Vascular endothelial growth factor (VEGF) plays a critical role in endothelial destruction and angiogenesis. Genetic variations of the VEGF gene have been associated with VEGF production. A study was undertaken to investigate the impact of VEGF(More)
Chronic atrioventricular (AV) block (CAVB) and biventricular hypertrophy in dogs increase susceptibility to drug-induced polymorphic ventricular tachycardia (PVT). In various rodent models, cyclosporin A (CsA) prevented hypertrophy. A similar effect in the CAVB model would allow us to determine whether hypertrophy represents an epiphenomenon, the cause of(More)
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