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1 For citation purposes: Scientific Opinion of the Panel on Animal Health and Welfare on a request from The European Commission on Animal health and welfare aspects of avian influenza and the risk of its introduction into the EU poultry holdings. SUMMARY Following a request from the Commission, the AHAW panel was asked to deliver a scientific opinion on the(More)
Interleukin-6 (IL-6) is overproduced in the joints of patients with rheumatoid arthritis (RA) and, based on its multiple stimulatory effects on cells of the immune system and on vascular endothelia, osteoclasts, and synovial fibroblasts, is believed to participate in the development and clinical manifestations of this disease. In this study we have analysed(More)
BACKGROUND Anemia due to impaired erythropoietin (EPO) production is associated with kidney failure. Recombinant proteins are commonly administered to alleviate the symptoms of this dysfunction, whereas gene therapy approaches envisaging the delivery of EPO genes have been tried in animal models in order to achieve stable and long-lasting EPO protein(More)
RATIONALE Latent infection with Mycobacterium tuberculosis is defined by a positive IFN-γ release assay (IGRA) result in the absence of active tuberculosis. Only few, mostly monocentric studies have evaluated the role of IGRAs to predict the development of tuberculosis in recent contacts in low-incidence countries of tuberculosis. OBJECTIVES To analyze(More)
Systemic and localized inflammation elicit a number of host responses which include fever, cachexia, hypoglycemia, and major changes in the concentration of liver plasma proteins. Interlenkin 6 (IL-6) is considered an important mediator of the inflammatory response, together with IL-1 and tumor necrosis factor c~ (TNF-c 0. The purpose of this study was to(More)
378 Alternative Methods: 3Rs, Research and Regulatory Aspects Francesca Caloni 1, Patrizia Costa , Gianni Dal Negro 3, Isabella De Angelis 4, Silvia Dotti 5, Giovanna Lazzari 6, Giacomo Metteucci 7, and Augusto Vitale 8 Università degli Studi di Milano, Department of Health, Animal Science and Food Safety, Milan, Italy; Università degli studi di Milano,(More)
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