Patrick Walters

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The activity cliff concept has experienced increasing interest in medicinal chemistry and chemoinformatics. Activity cliffs have originally been defined as pairs of structurally similar compounds that are active against the same target but have a large difference in potency. Activity cliffs are relevant for structure-activity relationship (SAR) analysis and(More)
B. Alver,1 B. B. Back,2 M. D. Baker,3 M. Ballintijn,1 D. S. Barton,3 R. R. Betts,4 R. Bindel,5 W. Busza,1 Z. Chai,3 V. Chetluru,4 E. Garcı́a,4 T. Gburek,6 K. Gulbrandsen,1 J. Hamblen,7 I. Harnarine,4 C. Henderson,1 D. J. Hofman,4 R. S. Hollis,4 R. Hołyński,6 B. Holzman,3 A. Iordanova,4 J. L. Kane,1 P. Kulinich,1 C. M. Kuo,8 W. Li,1 W. T. Lin,8 C. Loizides,1(More)
The hand dressing is a vital part of postoperative care and treatment of hand injuries. Changing a hand dressing can be a frustrating and traumatic experience for the patient and the person changing the dressing. By applying the basic principles and following the steps found in this article, changing a hand dressing becomes a simple procedure that(More)
Citation Alver, B. et al. " Event-by-Event Fluctuations of Azimuthal Particle Anisotropy in Au+Au Collisions at [sqrt]sNN=200 GeV. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please(More)
Citation Alver, B. et al. " Charged-particle multiplicity and pseudorapidity distributions measured with the PHOBOS detector in Au+Au, Cu+Cu, d+Au, and p+p collisions at ultrarelativistic energies. " Physical Review C 83. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the(More)
In 2012, we reported 30 compound data sets and/or programs developed in our laboratory in a data article and made them freely available to the scientific community to support chemoinformatics and computational medicinal chemistry applications. These data sets and computational tools were provided for download from our website. Since publication of this data(More)
Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications. Herein we describe up-to-date versions of three MMP-based data sets that have originated from in-house research projects. These data sets include(More)
In 2012, we reported 30 compound data sets and/or programs developed in our laboratory in a data article and made them freely available to the scientific community to support chemoinformatics and computational medicinal chemistry applications. These data sets and computational tools were provided for download from our website. Since publication of this data(More)
1 Acknowledgments: We would like to thank Estella Scruggs, Corporate Research Analyst of The City of Calgary, for her help in data collection and graphic design during the preparation of the manuscript. The views expressed in this paper are personal views of the authors. They do not necessarily represent the views of The City of Calgary 2 Abstract Over the(More)