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OBJECTIVE To determine the risks of hospitalisation for bleeding peptic ulcer with the current prophylactic aspirin regimens of 300 mg daily or less. DESIGN A case-control study with hospital and community controls. SETTING Hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth. SUBJECTS 1121 patients with gastric or duodenal ulcer(More)
Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of peptic ulcer complications, but it is not clear whether some drugs are more likely than others to cause such complications. We compared previous use of NSAIDs in 1144 patients aged 60 and older admitted to hospitals in five large cities with peptic ulcer(More)
AIMS To determine risk factors for peptic ulcer bleeding other than non-steroidal anti-inflammatory drugs (NSAIDs). Methods-Data on possible antecedent risk factors obtained in a large case control study of 1121 patients admitted to hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth with bleeding peptic ulcers were compared with the same(More)
Prior research had indicated that moderate maternal ethanol consumption during gestation affected the growth of the corpus callosum and anterior commissure in BALB/c mice when measured at day 19 postconception. Our purpose was to assess whether or not this was an enduring effect. Pregnant BALB/cCRBL mice were fed ethanol 10% v/v in the drinking water from(More)
The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used because it is prone to developing a corpus(More)
Series of fetuses from two inbred mouse strains, BALB/cCF and C57BL/6J, were collected at the time during which the corpus callosum (CC) crosses midline. Fetuses from each strain were matched initially with respect to chronological age, then morphological age and finally brain weight, and in each case the CC was assessed for presence at midline. The results(More)
The development of two forebrain fiber tracts, the anterior commissure (CA) and corpus callosum (CC), was examined in BALB/cCF laboratory mice in relation to the maternal dietary protein concentration during gestation. The diets contained either 8 or 27% casein. The BALB/c strain was used because it is prone to having a corpus callosum which is either(More)
The aim of this study was to compare the effects of malnutrition on behavioral development in mice with those due to heredity obtained in a previous study. To this end behavioral development was assessed using a developmental time scale which allowed comparison of the two studies. Pregnant B6D2F1/J mice were maintained on either a protein restricted or(More)
Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of liver disease from simple steatosis, to steatohepatitis, (both with and without liver fibrosis), cirrhosis and end-stage liver failure. NAFLD also increases the risk of hepatocellular carcinoma (HCC) and both HCC and end stage liver disease may markedly increase risk of liver-related(More)
PURPOSE OF REVIEW This review aims to assess the epidemiological evidence for a link between type 2 diabetes and hepatocellular carcinoma and to investigate possible pathophysiological mechanisms. RECENT FINDINGS The presence of type 2 diabetes significantly increases the risk of developing hepatocellular carcinoma, and treatment with metformin may be(More)