Patrick Thompson

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Activated protein C (APC) is a physiological serine protease that regulates blood clotting and inflammation. Keratinocytes are a major cell type of human skin and play a fundamental role in normal skin metabolism and cutaneous wound healing. In this study, we investigated the regulatory role of APC on the function of human primary cultured keratinocytes. In(More)
E-proteins are critical transcription factors in B-cell lymphopoiesis. E2A, 1 of 3 E-protein-encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein. An interaction involving a region within the N-terminal(More)
Non-Fc-receptor binding anti-CD3 Ab therapy, in the setting of several different autoimmune disorders, can induce antigen-specific and long-lasting immunologic tolerance. Because factor VIII (FVIII) inhibitor formation is the most serious treatment-related complication for hemophilia A patients, we tested the efficacy of anti-CD3 to prevent FVIII inhibitor(More)
In experimental systems, it has been shown that biodiversity indices based on traits or phylogeny can outperform species richness as predictors of plant ecosystem function. However, it is unclear whether this pattern extends to the function of food webs in natural ecosystems. Here we tested whether zooplankton functional and phylogenetic diversity explains(More)
The role of fire in UK upland management: the need for informed challenge to conventional wisdoms: a comment on Davies et al. Davies et al. [1] argue that prescribed burning is an important ecological management tool with deep, historical roots and that debate about the role of fire in management of the UK uplands should be informed and unbiased. We agree(More)
(535 articles) Thrombosis and Hemostasis (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication. the indexed by PubMed from initial publication. Citations to Advance(More)
We define a new approach to speech recognition based on auditory perception and modeled after the human brain's tendency to automatically categorize speech sounds [House 1962; Liberman 1957]. As background, today's speech recognition systems are knowledge-driven since they require the existence of word and syntax-level knowledge to identify a word from the(More)