Patrick T Yang

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We appraised organ-specific toxicokinetics and dose responses of arsenic burdens in tilapia Oreochromis mossambicus. We kinetically linked an Area-under-the-curve (AUC)-based acute toxicity model and a pharmacodynamic model to derive dose-response relationships between equilibrium organ-specific arsenic concentrations and mortality effects. The AUC-based(More)
Agaricus blazei Murill, an edible mushroom, shows immunomodulatory and antitumor activities (1–5). In Brazil, this fungus is used as a traditional medicine for the prevention of cancer, diabetes, hyperlipidemia, arteriosclerosis and chronic hepatitis. The polysaccharides, proteoglycans, polysaccharide–protein complexes, glycoproteins and steroids from(More)
We report three paediatric cases, and summarise the reported experience in two others, with cardiorespiratory failure requiring extracorporeal life support for which supportive pump flows could not be maintained due to abdominal compartment syndrome. In two of our patients, the mechanism of abdominal compartment syndrome was massive intra-abdominal fluid(More)
BACKGROUND In utero gene transfer is a novel therapy for monogenic disorders diagnosed in the fetus. Enhanced biosafety alternatives to viral vectors include non-viral transfer agents such as chitosan. The purpose of this study was to evaluate in vitro and in utero gene transfer of reporter gene (GFP) using chitosan as a transfer vehicle. MATERIALS AND(More)
A rare case of a paraganglioma (extraadrenal pheochromocytoma) that complicated both pregnancy and the puerperium is described. The patient presented a confusing clinical picture simulating pregnancy-induced hypertension, which, after delivery, masqueraded as intractable fever of unknown origin. Computed tomography precisely identified the presence and(More)
Pterygium 46 Neoplasm 9 Persistent epithelial defect 8 Conjunctival surface reconstruction not otherwise specified 5 Chemical burn 5 Glaucoma bleb reconstruction 4 Peripheral corneal melt 3 Vernal or atopic keratoconjunctivitis 2 Corneal melt over lamellar graft 2 Herpes simplex virus corneal epithelial defect 2 Limbal stem cell deficiency 1 Corneal ulcer þ(More)
Upper eyelid blepharoplasty is one of the most common procedures performed worldwide for both functional and cosmetic indications. There is a high rate of patient satisfaction; however, in this era of social media, patient expectations are higher than ever. Today's digitally savvy patients expect perfect outcomes with no complications and rapid recovery. To(More)
Descemet-stripping automated endothelial keratoplasty has revolutionized the treatment of corneal endothelial disease. This procedure requires the removal of the Descemet membrane (DM) and the endothelium from the recipient cornea. We describe a simple technique to perform descemetorrhexis using an ophthalmic viscosurgical device to fill the anterior(More)