Patrick Rolland

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Gabapentin is a relatively new anticonvulsant indicated for adjunctive therapy in the treatment of partial seizures, with and without secondary generalization, in adults with epilepsy. Overall, it has a minimal side effect profile compared with other anticonvulsant agents. Postmarketing surveillance is needed to further delineate the spectrum of adverse(More)
BACKGROUND The chemokine CXCL12 and its cognate receptor, CXCR4, have been implicated in numerous tumour types where expression promotes tumour growth, angiogenesis, metastasis and suppresses tumour immunity. METHODS Using a tissue microarray of 289 primary ovarian cancers coupled to a comprehensive database of clinicopathological variables, the(More)
15 cases of haemolytic uraemic syndrome (HUS) or bloody diarrhoea have been identified in the Gironde, southwest France. Investigations suggest the vehicle of transmission was sprouts, served at an event in Bègles on 8 June 2011. A strain of shiga toxin-producing Escherichia coli O104:H4 has been isolated from five cases. This strain is genetically related(More)
BACKGROUND An outbreak of haemolytic uraemic syndrome (HUS) due to Shiga toxin-secreting Escherichia coli (STEC) O104:H4 from contaminated fenugreek sprouts occurred in June 2011 near Bordeaux, France. In the context of this outbreak, all patients were treated with the monoclonal anti-C5 antibody, eculizumab. METHODS The diagnosis of HUS was made based on(More)
BACKGROUND In the course of setting up the National Mesothelioma Surveillance Program (PNSM), established in France in 1998, the question arose as to the most suitable method of assessing occupational exposure. The aim of this study was to define the most suitable rating method for assessing occupational asbestos exposure in order to assess medico-social(More)
Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using the DSM-IV criteria, the Hamilton(More)
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