Patrick R Hunt

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Groups of rats received cytotoxic lesions centred in either the anterior thalamic nucleus (AM), the anterior ventral and anterior dorsal thalamic nuclei (AV/AD), or all three nuclei combined (ANT.T). These lesions were made by injecting N-methyl-D-aspartate acid (NMDA). These rats, and a group of surgical controls (SHAM), were trained on a rewarded(More)
The effects of cytotoxic lesions in either the anterior thalamic nuclei or the mamillary bodies were compared with those of fornix lesions on a test of spatial working memory. All three lesions impaired acquisition of a forced alternation task in a T-maze, but the disruptive effects of the mamillary body lesions were significantly less than those following(More)
A series of experiments examined the proposal that the primary effect of hippocampal damage in rats is to disrupt working memory. Although extensive hippocampal lesions produced a severe impairment in forced-choice alternation--a test of spatial working memory--the same lesions did not impair the acquisition of a non-spatial test of working memory--delayed(More)
Pigmented rats of the DA strain with either radiofrequency or ibotenic acid lesions of the thalamic nucleus medialis dorsalis were postoperatively given nonspatial and spatial tests of working memory. In the nonspatial task, delayed nonmatching-to-sample, rats with both types of thalamic lesions showed acquisition impairments. The subgroup of rats with(More)
To provide molecular and virologic evidence that domestic dog rabies is no longer enzootic to the United States and to identify putative relatives of dog-related rabies viruses (RVs) circulating in other carnivores, we studied RVs associated with recent and historic dog rabies enzootics worldwide. Molecular, phylogenetic, and epizootiologic evidence shows(More)
This study examined the acquisition of a T-maze matching to place task by rats with neurotoxic lesions of the thalamic nucleus medialis dorsalis. This test of spatial working memory also entails learning a task rule that is contrary to the animals' innate preference. The rats next performed the same matching task over different retention delays. Finally,(More)
A series of experiments compared the effects of mammillary body lesions with those of combined damage to the amygdala and fornix on 2 tests of working memory, both of which used the delayed non-matching-to-sample rule. This comparison was based on evidence of the involvement of these regions in anterograde amnesic syndromes. The mammillary body lesions had(More)
Rats with radiofrequency lesions of the fimbria/fornix or with extensive aspiration lesions of the hippocampal region (the hippocampus proper, dentate gyrus, and subicular complex) were tested on their performance of a delayed non-matching to position task which had been learnt before surgery. On a given trial, one of two sample levers was presented in a(More)
The present study examined the performance of rats with neurotoxic lesions centred in the thalamic nucleus medialis dorsalis on standard and modified versions of the eight arm radial maze test. In Experiment 1, the thalamic lesions produced a borderline deficit in acquisition of the standard task, but subsequently had no effect when a delay was interposed(More)
OBJECTIVE To obtain epidemiologic information on rabies in skunks in Texas. DESIGN Epidemiologic study. SAMPLE POPULATION Reports of skunks that had been submitted for rabies testing in Texas from 1953 through 2007. PROCEDURES Reports were reviewed to obtain information on seasonality of rabies in skunks, seasonality of human and domestic animal(More)