Patrick O'Dea

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A homologue of mammalian type II interleukin-1 receptor (IL-1RII) was isolated from a rainbow trout cDNA library by differential hybridization using a suppression subtractive hybridization generated probe enriched for sequences upregulated after immune stimulation. The trout cDNA has an ORF encoding 441 amino acids, and represents the first piscine IL-1(More)
Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammatory response and its elevation has recently been shown to be a poor prognostic factor in many malignancies including colon, prostate and bladder cancer. The primary aim of this study was to assess the prognostic impact of NLR in a clinically annotated cohort of patients with glioblastoma(More)
Sitting is a common aggravating factor in low back pain (LBP), and re-education of sitting posture is a common aspect of LBP management. However, there is debate regarding what is an optimal sitting posture. This pilot study had 2 aims; to investigate whether pain-free subjects can be reliably positioned in a neutral sitting posture (slight lumbar lordosis(More)
Magnetic Resonance Imaging (MRI) is known to be significantly affected by a number of acquisition artifacts, such as intensity non-standardness, bias field, and Gaussian noise. These artifacts degrade MR image quality significantly, obfuscating anatomical and physiological detail and hence need to be corrected for to facilitate application of computerized(More)
e19621 Background: In an aging cancer population treatment decisions become more complex. Treatment options in GBM are increasing and there is a paucity of data in the elderly (>65 years). We sought to review our institution's experience of treating this patient (pt) population. METHODS A prospectively maintained database was evaluated for pts with GBM(More)
e12516 Background: GBM is an aggressive malignancy with a poor outcome. Retrospective studies have correlated clinicopathologic and molecular variables with prognosis and constructed nomograms predicting outcome. We identified long-term survivors (LTS) in an Irish neuro-oncology center and investigated associations with patient and tumoral variables. (More)
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