Patrick O'Connell

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BACKGROUND Hippocampal volume reduction has been repeatedly demonstrated in schizophrenia. The relative contribution of genetic and environmental factors to this is unclear. METHODS To address this question, we compared volumetric measurements of the left and right hippocampus, obtained using stereological methods from brain MRI scans, from two groups of(More)
Over a century ago, the Scottish psychiatrist Thomas Clouston proposed the idea of a developmental or adolescent insanity. He characterised the condition as having a male predominance and a poor outcome, and noted the frequency of a family history and of minor anomalies of the palate; he considered it a disorder of cortical development and the onset of(More)
We describe the GENI Experiment Engine, a Distributed-Platform-as-a-Service facility designed to be implemented on a distributed testbed or infrastructure. The GEE is intended to provide rapid and convenient access to a distributed infrastructure for simple, easy-to-configure experiments and applications. Specifically, the design goal of the GEE is to(More)
The novel antipsychotic drug sertindole has an atypical pharmacological profile. We have estimated striatal D2 dopamine binding in schizophrenic patients treated with sertindole using 123I iodobenzamide (IBZM) SPET. Patients were recruited from a clinical trial of sertindole's tolerability and efficacy. Striatal D2 binding in sertindole-treated patients (n(More)
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