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Models were developed to predict the bioconcentration of well-metabolized chemicals by rainbow trout. The models employ intrinsic clearance data from in vitro studies with liver S9 fractions or(More)
Scientists studying mammals have developed a stepwise approach to predict in vivo hepatic clearance from measurements of in vitro hepatic biotransformation. The resulting clearance estimates have(More)
A physiologically based toxicokinetic (PBTK) model was developed to describe dietary uptake of hydrophobic organic compounds by fish. The gastrointestinal (GI) tract was modeled using four(More)