Patrick Morse

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Cyclic strain has been shown to benefit tendon health. However, repetitive loading has also been implicated in the etiology of tendon overuse injuries. Recent studies demonstrated that in several cell lines cyclic strain was associated with an activation of stress-activated protein kinases (SAPKs). These SAPKs, in turn, were shown to be important upstream(More)
BACKGROUND Experimental studies have shown that endothelial dysfunction is an early event preceding restenosis. Monocytes and neutrophils have been shown to bind to damaged endothelium via the cell adhesion molecules (CAMs). The selectins are involved in capturing the leukocytes and tethering them to the endothelium. E-selectin is a CAM that is only(More)
BACKGROUND The Situational Construal Model proposes that characteristics of persons and situations interact to influence construal of situations and resultant behavior. We apply this framework to the study of healthcare experiences in two studies. METHODS In Study 1, mTurk users (N = 670) read vignettes of positive, neutral, or negative healthcare(More)
A randomized, nonblinded study was carried out to evaluate the efficacy of a single 2-g oral dose of metronidazole (Flagyl) versus a seven-day regimen in the treatment of "nonspecific" vaginitis. Using cultures for Gardnerella vaginalis, 14 (67%) of 21 women treated with the single 2-g dose and 19 (86%) of 21 women receiving the seven-day course were(More)
Imaging technologies such as cine-radiography, cine-MRI, and X-ray stereo photogrammetry have become popular diagnostic tools in biomechanical studies of musculoskeletal systems. However, their widespread use for research purposes has been restricted due to their high cost and somewhat limited availability. In an attempt to develop a reliable low cost(More)
Cell-free extracts of the human rhabdomyosarcoma cell line HUS-2 caused the transformation of human embryo fibroblasts. This transformation included morphologic alteration, karyotypic change, and an increase in culture longevity. With the use of sex markers, multiple karyotypes confirmed that the human embryo fibroblasts were transformed, and the use of(More)
Sixty-five patients with mild to moderate nonproliferative diabetic retinopathy who enrolled in a prospective controlled clinical trial had stereofundus photographs assessed for change over an 8-mo period. The entire study group showed a worsening of retinopathy with time (P less than 0.001). The worsening was greater in the pump-treated group (15/32) than(More)