Raymon Durso15
Erica Harris9
Sanford Auerbach6
Ariel Brown6
15Raymon Durso
9Erica Harris
6Sanford Auerbach
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BACKGROUND Pragmatic communication abilities may depend on intact frontal lobe systems. Independent evidence suggests that some persons with Parkinson's disease (PD) are impaired on measures of frontal lobe function. HYPOTHESIS We therefore hypothesized in Study 1 that pragmatic communication skills would be impaired in some persons with PD and would be(More)
OBJECTIVE To study clinical correlates of religiosity in Parkinson's disease (PD). METHODS Measures of life goals, religiosity, mood, and neuropsychologic function were assessed in 22 persons with mid-stage PD and 20 age-matched healthy controls. Levodopa dose equivalents (LDE) were also computed for the patients. RESULTS Relative to other major life(More)
BACKGROUND Sleep is a biological enigma. Despite occupying much of an animal's life, and having been scrutinized by numerous experimental studies, there is still no consensus on its function. Similarly, no hypothesis has yet explained why species have evolved such marked variation in their sleep requirements (from 3 to 20 hours a day in mammals). One(More)
The amount of time asleep varies greatly in mammals, from 3 h in the donkey to 20 h in the armadillo. Previous comparative studies have suggested several functional explanations for interspecific variation in both the total time spent asleep and in rapid-eye movement (REM) or "quiet" (non-REM) sleep. In support of specific functional benefits of sleep,(More)
This paper presents a new statistical methodology to simulate the effect of both inter-die and intra-die variation on the electrical performance of analog integrated circuits. The main feature of this methodology is that it accounts for device mismatch by using a number of variables that is asymptotically constant in the limit of perfectly matching devices,(More)
Alcohol is a known exogenous modulator of negative affect (anxiety, tension) in both animals and humans. It has been proposed that the anxiolytic effects of alcohol are mediated via the amygdala, an area critical to fear perception and responding. However, little is known about the acute effects of alcohol on amygdala reactivity to threatening information(More)
INTRODUCTION A number of reports have identified significant personality differences in patients with Parkinson's disease (PD) when compared with age-matched controls. We hypothesised that these differences may be related to impairment in prefrontal inhibitory functions resulting in the expression of new "Machiavellian" personality traits. METHODS(More)
A strong link exists between cigarette smoking and alcohol use, which may be explained by the experimental observation that alcohol ingestion promotes cigarette craving and precipitates smoking. At the neuroanatomic level, it is unclear where and how alcohol exerts these effects, although the process likely involves the ventral striatum given its function(More)
We review the literature on the neurobiology of rapid eye movement (REM) and non-rapid eye movement (NREM) sleep states and associated dreams. REM is associated with enhanced activation of limbic and amygdalar networks and decreased activation in dorsal prefrontal regions while stage II NREM is associated with greater cortical activation than REM. Not(More)