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Maintaining accurate world knowledge in a complex and changing environment is a perennial problem for robots and other artificial intelligence systems. Our architecture for addressing this problem, called Horde, consists of a large number of independent reinforcement learning sub-agents, or demons. Each demon is responsible for answering a single predictive(More)
A general problem for human-machine interaction occurs when a machine's controllable dimensions outnumber the control channels available to its human user. In this work, we examine one prominent example of this problem: amputee switching between the multiple functions of a powered artificial limb. We propose a dynamic switching approach that learns during(More)
One of the hottest topics in rehabilitation robotics is that of proper control of prosthetic devices. Despite decades of research, the state of the art is dramatically behind the expectations. To shed light on this issue, in June, 2013 the first international workshop on Present and future of non-invasive peripheral nervous system (PNS)-Machine Interfaces(More)
As a contribution toward the goal of adaptable, intelligent artificial limbs, this work introduces a continuous actor-critic reinforcement learning method for optimizing the control of multi-function myoelectric devices. Using a simulated upper-arm robotic prosthesis, we demonstrate how it is possible to derive successful limb controllers from myoelectric(More)
Incremental learning algorithms based on gradient descent are effective and popular in online supervised learning, reinforcement learning, signal processing, and many other application areas. An oft-noted drawback of these algorithms is that they include a step-size parameter that needs to be tuned for best performance, which may require manual intervention(More)
— Reinforcement learning methods are often considered as a potential solution to enable a robot to adapt to changes in real time to an unpredictable environment. However, with continuous action, only a few existing algorithms are practical for real-time learning. In such a setting, most effective methods have used a parameterized policy structure, often(More)
Predicting the future has long been regarded as a powerful means to improvement and success. The ability to make accurate and timely predictions enhances our ability to control our situation and our environment. Assistive robotics is one prominent area in which foresight of this kind can bring improved quality of life. In this article, we present a new(More)
Interphase fluorescence in situ hybridisation (FISH) is a sensitive diagnostic tool used for the detection of alterations in the genome on cell-by-cell basis. However, the cost-per-test and the technical complexity of current FISH protocols have slowed its widespread utilisation in clinical settings. For many cancers, the lack of a cost-effective and(More)
PURPOSE Despite new treatments, acute myeloid leukemia (AML) remains an incurable disease. More effective drug design requires an expanded view of the molecular complexity that underlies AML. Alternative splicing of RNA is used by normal cells to generate protein diversity. Growing evidence indicates that aberrant splicing of genes plays a key role in(More)