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- Clifford B. Saper, Patrick M Fuller, Nigel P Pedersen, Jun Lu, Thomas E Scammell
- Neuron
- 2010
We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow… (More)
- Patrick M Fuller, David Sherman, Nigel P Pedersen, Clifford B. Saper, Jun Lu
- The Journal of comparative neurology
- 2011
The "ascending reticular activating system" theory proposed that neurons in the upper brainstem reticular formation projected to forebrain targets that promoted wakefulness. More recent formulations… (More)
- Patrick M Fuller, Jun Lu, Clifford B. Saper
- Science
- 2008
When food is plentiful, circadian rhythms of animals are powerfully entrained by the light-dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift… (More)
- Patrick M Fuller, Joshua J. Gooley, Clifford B. Saper
- Journal of biological rhythms
- 2006
This mini-review article presents the remarkable progress that has been made in the past decade in our understanding of the neural circuitry underlying the regulation of sleep-wake states and… (More)
- Christelle Anaclet, Nigel P Pedersen, Patrick M Fuller, Jun Lu
- PloS one
- 2010
BACKGROUND
Rapid eye movement sleep (REMS) is characterized by activation of the cortical and hippocampal electroencephalogram (EEG) and atonia of non-respiratory muscles with superimposed phasic… (More)
- Heinrich S. Gompf, Christine Mathai, +4 authors Jun Lu
- The Journal of neuroscience : the official…
- 2010
Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in… (More)
- Mei-hong Qiu, Ramalingam Vetrivelan, Patrick M Fuller, Jun Q. Lu
- The European journal of neuroscience
- 2010
The basal ganglia (BG) are involved in numerous neurobiological processes that operate on the basis of wakefulness, including motor function, learning, emotion and addictive behaviors. We… (More)
- Yo Oishi, Rhiannan H. Williams, +5 authors Thomas E Scammell
- The Journal of neuroscience : the official…
- 2013
Narcolepsy is characterized by chronic sleepiness and cataplexy, episodes of profound muscle weakness that are often triggered by strong, positive emotions. Narcolepsy with cataplexy is caused by a… (More)
- Christelle Anaclet, Nigel P Pedersen, +4 authors Patrick M Fuller
- Nature communications
- 2015
Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal forebrain (BF). BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic drugs have… (More)
- Patrick M Fuller, Clifford B. Saper, Jun Lu
- The Journal of physiology
- 2007
Rapid eye movement (REM) sleep is a behavioural state characterized by activation of the cortical and hippocampal EEG, rapid eye movements and muscle atonia. For the past 30 years, the most widely… (More)