Patrick M Fuller

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Clifford B. Saper, Patrick M Fuller, Nigel P. Pedersen, Jun Lu, Thomas E Scammell
Neuron
2010

We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow… (More)

Differential rescue of light- and food-entrainable circadian rhythms.

Patrick M Fuller, Jun Lu, Clifford B. Saper
Science
2008

When food is plentiful, circadian rhythms of animals are powerfully entrained by the light-dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift… (More)

Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback.

Patrick M Fuller, Joshua J. Gooley, Clifford B. Saper
Journal of biological rhythms
2006

This mini-review article presents the remarkable progress that has been made in the past decade in our understanding of the neural circuitry underlying the regulation of sleep-wake states and… (More)

Reassessment of the structural basis of the ascending arousal system.

Patrick M Fuller, David Sherman, Nigel P. Pedersen, Clifford B. Saper, Jun Lu
The Journal of comparative neurology
2011

The "ascending reticular activating system" theory proposed that neurons in the upper brainstem reticular formation projected to forebrain targets that promoted wakefulness. More recent formulations… (More)

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

Dong Geon Kong, Qingchun Tong, +7 authors Bradford B. Lowell
Cell
2012

Neural regulation of energy expenditure is incompletely understood. By genetically disrupting GABAergic transmission in a cell-specific fashion, and by combining this with selective pharmacogenetic… (More)

Brainstem Circuitry Regulating Phasic Activation of Trigeminal Motoneurons during REM Sleep

Christelle Anaclet, Nigel P. Pedersen, Patrick M Fuller, Jun Lu
PloS one
2010

BACKGROUND Rapid eye movement sleep (REMS) is characterized by activation of the cortical and hippocampal electroencephalogram (EEG) and atonia of non-respiratory muscles with superimposed phasic… (More)

Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal.

Satvinder Kaur, Nigel P. Pedersen, +5 authors Clifford B. Saper
The Journal of neuroscience : the official…
2013

The mechanisms of arousal from apneas during sleep in patients suffering from obstructive sleep apnea are not well understood. However, we know that respiratory chemosensory pathways converge on the… (More)

The pontine REM switch: past and present.

Patrick M Fuller, Clifford B. Saper, Jun Lu
The Journal of physiology
2007

Rapid eye movement (REM) sleep is a behavioural state characterized by activation of the cortical and hippocampal EEG, rapid eye movements and muscle atonia. For the past 30 years, the most widely… (More)

Brainstem and Spinal Cord Circuitry Regulating REM Sleep and Muscle Atonia

Martina Krenzer, Christelle Anaclet, +5 authors Jun Lu
PloS one
2011

BACKGROUND Previous work has suggested, but not demonstrated directly, a critical role for both glutamatergic and GABAergic neurons of the pontine tegmentum in the regulation of rapid eye movement… (More)

Identification and characterization of a sleep-active cell group in the rostral medullary brainstem.

Christelle Anaclet, Jian-Sheng Lin, +4 authors Jun Lu
The Journal of neuroscience : the official…
2012

Early transection and stimulation studies suggested the existence of sleep-promoting circuitry in the medullary brainstem, yet the location and identity of the neurons comprising this putative… (More)

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