Patrick Le Pivert

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Strategies to enhance the already established doublet chemotherapy regimen for lung cancer have been investigated for more than 20 years. Initially, the concept was to administer chemotherapy drugs locally to the tumor site for efficient diffusion through passive transport within the tumor. Recent advances have enhanced the diffusion of pharmaceuticals(More)
Modern approaches to minimally invasive ablative treatment of solid tumors involve the use of miniature instruments and combined treatments. These can be enhanced with ultrasound imaging that depicts tumor margins; facilitates guidance, delivery, and dosage of local chemotherapy; and can monitor the effectiveness of the treatment. This paper describes the(More)
The idea of applying cryosurgery to the treatment of lower extremities varicose veins originated in 1978 from three developments: The increasing abundance of experimental and clinical observations of the vascular effect of low temperatures. The development of a more suitable, flexible instrumentation, in collaboration with the Atomic Energy Commissary. The(More)
A study of 10 cases of villous tumors treated by cryosurgery shows that this is a simple, benign, and conservative method which can be repeated if need be. It is possible to associate this method with other methods, in particular radiotherapy. The first results obtained suggest that cryosurgery can take its place amongst all the other non-invasive methods(More)
Study of the intrinsic vascularization of the oesophagus in eleven organs. A technic of microangiography was used. The thoracic portion of the oesophagus was carefully studied. The way of penetration of the nutrient arteries and the intraparietal vascular pattern were precised. The vascularization is rather poor, especially 4-5 cms above the oesophagal(More)
We have developed an outpatient technique for high-risk varicose patients, using local anesthesia and cryo-sclerosis of the vein wall. A flexible cryo-probe is introduced in the vessel lumen, and its tip refrigerated to --89 degrees C. Thrombosis is thus induced with a limited inflammatory reaction and no pain. The vein then undergoes a progressive(More)
An association of bacterial ribosomes and cell-wall of Klebsiella pneumoniae was shown to reduce the incidence of an epidermoid carcinoma in Sprague-Dawley rats when administered subcutaneously prior the tumoral graft. Mononuclear cells accumulate around the tumor. This association was considered as a non specific adjuvant stimulating the host's intrinsic(More)