Patrick Le Pivert

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Modern approaches to minimally invasive ablative treatment of solid tumors involve the use of miniature instruments and combined treatments. These can be enhanced with ultrasound imaging that depicts tumor margins; facilitates guidance, delivery, and dosage of local chemotherapy; and can monitor the effectiveness of the treatment. This paper describes the(More)
Lung cancer still remains to be challenged by novel treatment modalities. Novel locally targeted routes of administration are a methodology to enhance treatment and reduce side effects. Intratumoral gene therapy is a method for local treatment and could be used either in early-stage lung cancer before surgery or at advanced stages as palliative care. Novel(More)
Strategies to enhance the already established doublet chemotherapy regimen for lung cancer have been investigated for more than 20 years. Initially, the concept was to administer chemotherapy drugs locally to the tumor site for efficient diffusion through passive transport within the tumor. Recent advances have enhanced the diffusion of pharmaceuticals(More)
The idea of applying cryosurgery to the treatment of lower extremities varicose veins originated in 1978 from three developments: The increasing abundance of experimental and clinical observations of the vascular effect of low temperatures. The development of a more suitable, flexible instrumentation, in collaboration with the Atomic Energy Commissary. The(More)
Study of the intrinsic vascularization of the oesophagus in eleven organs. A technic of microangiography was used. The thoracic portion of the oesophagus was carefully studied. The way of penetration of the nutrient arteries and the intraparietal vascular pattern were precised. The vascularization is rather poor, especially 4-5 cms above the oesophagal(More)
This acute study was aimed at exploring the ability of a cryoablative lesion to drive the distribution of a concomitant in situ injection of a free epirubicin-ethanol-ethiodol-methylene blue mixture. We report the feasibility and safety of this new percutaneous computed tomography-guided combinatorial ablative procedure on VX2 tumors. Eight New Zealand(More)
We have developed an outpatient technique for high-risk varicose patients, using local anesthesia and cryo-sclerosis of the vein wall. A flexible cryo-probe is introduced in the vessel lumen, and its tip refrigerated to --89 degrees C. Thrombosis is thus induced with a limited inflammatory reaction and no pain. The vein then undergoes a progressive(More)