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The objective of this study was to evaluate the initial fixation strength of a biodegradable interference screw compared with press-fit fixation and a titanium interference screw in anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft. Porcine lower limbs were used. The specimens underwent 500 loading cycles between 60 and 250(More)
The objective of this study was to evaluate the fixation strength of a biodegradable interference screw (Arthrex, Naples, FL) compared with press fit fixation and a titanium interference screw in anterior cruciate ligament (ACL) reconstruction using a bone-patellar tendon-bone (BPTB) graft. Porcine lower limbs were used. Ultimate failure loads of the(More)
The pore size of biopolymer networks governs their mechanical properties and strongly impacts the behavior of embedded cells. Confocal reflection microscopy and second harmonic generation microscopy are widely used to image biopolymer networks; however, both techniques fail to resolve vertically oriented fibers. Here, we describe how such directionally(More)
We present a method to reconstruct a disordered network of thin biopolymers, such as collagen gels, from three-dimensional (3D) image stacks recorded with a confocal microscope. The method is based on a template matching algorithm that simultaneously performs a binarization and skeletonization of the network. The size and intensity pattern of the template(More)
The objective of this study was to evaluate the initial fixation strength of a metal interference screw (9 x 25 mm; Arthrex, Naples, FL) with respect to its position relative to the bone plug in anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft. Porcine lower limbs were used. In group 1 (n = 20) the screw was placed adjacent(More)
Subjective tinnitus is generally assumed to be a consequence of hearing loss. In animal studies it has been demonstrated that acoustic trauma induced cochlear damage can lead to behavioral signs of tinnitus. In addition it was shown that noise trauma may lead to deafferentation of cochlear inner hair cells (IHC) even in the absence of elevated hearing(More)
Noise induced hearing loss (NIHL) is a common disease in modern societies and may lead to maladaptations within the auditory system that finally result in subjective tinnitus. Available therapies may only alleviate the symptoms rather than restore normal hearing. In a previous study we demonstrated that the prophylactic application of Ginkgo biloba extract(More)
We present a new statistical method to analyze multichannel steady-state local field potentials (LFP) recorded within different sensory cortices of different rodent species. Our spatiotem-poral multi-dimensional cluster statistics (MCS) method enables statistical analyzing and comparing clusters of data points in n-dimensional space. We demonstrate that(More)
Successful detection of weak signals is a universal challenge for numerous technical and biological systems and crucially limits signal transduction and transmission. Stochastic resonance (SR) [1] has been identified to have the potential to tackle this problem, namely to enable non-linear systems to detect small, otherwise sub-threshold signals by means of(More)