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At its most fundamental level, cerebral blood flow (CBF) may be modeled as fluid flow driven through a network of resistors by pressure gradients. The composition of the blood as well as the cross-sectional area and length of a vessel are the major determinants of its resistance to flow. Here, we introduce a vascular graph modeling framework based on these(More)
The Multiscale Finite-Volume (MSFV) method has been recently developed and tested for multiphase-flow problems with simplified physics (i.e. incompressible flow without gravity and capillary effects) and proved robust, accurate and efficient. However, applications to practical problems necessitate extensions that enable the method to deal with more complex(More)
BACKGROUND Type III secretion systems (TTSS) are employed by numerous pathogenic and symbiotic bacteria to inject a cocktail of different "effector proteins" into host cells. These effectors subvert host cell signaling to establish symbiosis or disease. METHODOLOGY/PRINCIPAL FINDINGS We have studied the injection of SipA and SptP, two effector proteins of(More)
MMS features research articles that focus on the fundamental modeling and computational principles underlying various multiscale methods. Multiscale modeling is highly interdisciplinary, with developments occurring independently across fields. Research papers and survey articles that augment the fundamental ways we model and predict multiscale phenomena are(More)
Targeting of permissive entry sites is crucial for bacterial infection. The targeting mechanisms are incompletely understood. We have analyzed target-site selection by S. Typhimurium. This enteropathogenic bacterium employs adhesins (e.g. fim) and the type III secretion system 1 (TTSS-1) for host cell binding, the triggering of ruffles and invasion.(More)
We present a multiscale finite-volume (MSFV) method for multiphase flow and transport in heterogeneous porous media. The approach extends our recently developed MSFV method for single-phase flow. We use a sequential scheme that deals with flow (i.e., pressure and total velocity) and transport (i.e., saturation) separately and differently. For the flow(More)
We describe a sequential fully implicit (SFI) multi-scale finite volume (MSFV) algorithm for nonlinear multi-phase flow and transport in heterogeneous porous media. The method extends the recently developed multiscale approach, which is based on an IMPES (IMplicit Pressure, Explicit Saturation) scheme [P.scale finite volume method for multi-phase flow and(More)