Patrick J. van der Geest

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Five patients had absence seizures refractory to treatment with either ethosuximide or valproate sodium. To determine their response to combination therapy with the two drugs, four of the five had serial 24-hour intensive monitoring studies that included cable telemetric EEG recording, closed-circuit television observation, and frequent antiepileptic drug(More)
BACKGROUND Candida spp. are frequently cultured from the respiratory tract in critically ill patients. Most intensivists start amphotericin-B deoxycholate (ABDC) inhalation therapy to eradicate Candida spp. from the respiratory tract. However, the safety and efficacy of this treatment are not well established. The purpose of this study was to assess the(More)
BACKGROUND In critically ill patients the incidence of invasive fungal infections caused by Candida spp. has increased remarkably. Echinocandins are recommended as initial treatment for invasive fungal infections. The safety and efficacy of micafungin compared to caspofungin is similar, but no comparison is made between anidulafungin and micafungin(More)
BACKGROUND The prediction of infection and its severity remains difficult in the critically ill. A novel, simple biomarker derived from five blood-cell derived parameters that characterize the innate immune response in routine blood samples, the intensive care infection score (ICIS), could be helpful in this respect. We therefore compared the predictive(More)
Unfortunately, the original version of this supplement [1] contained errors in two of the abstracts; P037 and P127. Please see details below. In P037, the image presented as Figure eight is incorrect. The correct figure is shown below (Fig. 1). permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to(More)
Financial support by Astellas Pharma and Sysmex Europe for the publication of this thesis is gratefully acknowledged. Serious Infections in the Intensive Care Unit: diagnosis and management Ernstige infecties in de intensive care unit: diagnose en behandeling Thesis to obtain the degree of Doctor from the Erasmus University Rotterdam by command of the(More)
The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appeared to reduce diurnal paroxysmal(More)
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