Patrick J. Rogler

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The authors present a new method of lumbar phlebology without catheterism by direct venous puncture of the femoral veins. An analysis of 300 contrast tests maked it possible to identify different types of pathological images characterized by disappearance and displacement of epidural veins corresponding as a rule to discal hernia when the uncharacteristic(More)
Cannabinoid receptors 1 and 2 (CB1 and CB2, respectively) are part of the endocannabinoid system along with intracellular enzymes (such as fatty acid amide hydrolase, FAAH) that degrade endocannabinoid ligands. Exogenous cannabinoids are potential therapeutics for treating neurological sequalae in HIV-infected patients because cannabinoids can suppress the(More)
Following up on the characterization of a new (heme)Fe(III)-superoxide species formed from the cryogenic oxygenation of a ferrous-heme (P(Py))Fe(II) (1) (P(Py) = a tetraarylporphyrinate with a covalently tethered pyridine group as a potential axial base), giving (P(Py))Fe(III)-O2(•-) (2) (Li Y et al., Polyhedron 2013; 58: 60-64), we report here on (i) its(More)
A series of ferrous-heme 2,6-dimethylphenyl isocyanide (DIMPI) and ferrous-heme mononitrosyl complexes have been synthesized and characterized. The heme portion of the complexes studied is varied with respect to the nature of the axial ligand, including complexes, where it is covalently tethered to the porphyrinate periphery. Reduced heme complexes,(More)
Reductive cleavage of C6F5SeSeC6F5 with elemental M (M = Cu, In, Sn, Pb) in pyridine results in the formation of (py)4Cu2(SeC6F5)2, (py)2In(SeC6F5)3, (py)2Sn(SeC6F5)2, and (py)2Pb(SeC6F5)2. Each group adopts a unique structure: the Cu(I) compound crystallizes as a dimer with a pair of bridging selenolates, two pyridine ligands coordinating to each Cu(I)(More)
We have designed and synthesized a small library of 3,5-disubstituted-1,2,4-oxadiazole containing combretastatin A-4 (CA-4) analogs. Our objective is to increase the efficacy of the CA-4 as an anti-tubulin and antimitotic agent by substituting the cis-alkene bond with one of its bioisosteres, the 1,2,4-oxadiazole ring. We also modified the substituents(More)
We previously synthesized novel retinoid libraries, and after screening for bioactivity found one compound BT10 that functions as a specific agonist for retinoic acid receptors. This lead compound was further derivatized using SAR and LRD to obtain 3,5-disubstituted-1,2,4-oxadiazole-containing retinoids. The new oxadiazole (amide bioisosters)-containing(More)
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