Patrick J Pead

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A 7.5 kbp cryptic plasmid is found in almost all isolates of Chlamydia trachomatis. Real-time PCR assays, using TaqMan chemistry, were set up to quantify accurately both the chlamydial plasmid and the single copy, chromosomal omcB gene in the infectious, elementary bodies (EBs) of C. trachomatis L1 440. Plasmid copy number was also determined in the EBs of(More)
Hepatitis B vaccine (H. B. Vax), has been available for staff in the Portsmouth District Hospitals since 1983. Results from anti-HBs monitoring of recipients indicated high percentages of suboptimal responders and vaccine failures after three injections into the gluteal muscle. A single revaccination into the deltoid muscle boosted antibody status in(More)
A study was made of 20 patients fulfilling the criteria customarily used for the diagnosis of interstitial cystitis. A possible infective aetiology was sought by culture of bladder tissue, catheter and midstream specimens of urine, and urethral swabs by methods capable of detecting fastidious bacteria as well as aerobic pathogens. All bladder biopsies(More)
We examined some epidemiological features of the viruses associated with gastrointestinal illness, using national data reported by electron microscopists in the United Kingdom. During the 3 years analyzed (1985-1987), a total of 1,993 positive detections of astroviruses, caliciviruses, coronaviruses, and small round structured viruses (SRSVs) were reported.(More)
AIMS To test the hypothesis that single nucleotide polymorphisms (SNPs) within genes (or their promoter regions) encoding cytokines, growth factors, and intercellular adhesion molecules modulate the risk of development of chronic pancreatitis (CP). METHODS DNA was extracted from peripheral blood leucocytes or formalin fixed, paraffin wax embedded tissue(More)
An outbreak of gastroenteritis involving residents and members of staff in a nursing home for the elderly is described. The agent associated with this episode was a calicivirus which is serologically distinct from two strains causing gastroenteritis in children. We believe that this is the first report of calicivirus infection in adults.
Stools from 56 patients with gastroenteritis were cultured for Campylobacter jejuni. The five strains isolated were examined by electron microscopy. The campylobacter cells were pleomorphic and most displayed appearances similar to those of V. fetus. Morphological changes were observed in cultures subjected to prolonged incubation.