Patrick J. Kiel

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Thymoma and thymic carcinomas are rare epithelial tumors that arise from the thymus gland. Current management depends on staging, with surgery being the mainstay of therapy for stages I and II disease. Combined modality therapy, including radiation and chemotherapy, is recommended for patients who have invasive and metastatic disease. Relapse has been(More)
Trimethoprim-Rhabdomyolysis is a serious, potentially life-threatening complication diagnosed when creatine phosphokinase levels exceed 1000 U/L. Although many drugs are associated with rhabdomyolysis, the previous reports of trimethoprim-sulfamethoxazole (TMP/SMX)-induced rhabdomyolysis have involved patients with human immunodeficiency virus/acquired(More)
PATIENTS AND METHODS Patients with metastatic solid tumors who had progressed on at least one line of standard of care therapy were referred to the Indiana University Health Precision Genomics Program. Tumor samples were submitted for DNA & RNA next-generation sequencing, fluorescence in situ hybridization, and immunohistochemistry for actionable targets. A(More)
Amikacin is an aminoglycoside commonly used to provide empirical double gram-negative treatment for febrile neutropenia and other suspected infections. Strategies of extended-interval and conventional dosing have been utilized extensively in the general medical population; however, data are lacking to support a dosing strategy in the hematology/oncology(More)
Systemic amyloidosis (AL) is the deposition of amyloid fibrils derived from monoclonal light chains that are reproduced by clonal plasma cells. Without treatment, AL is fatal within 2 years, secondary to fibril deposits in vital organs. The disease course depends on halting monoclonal light chain production. Early assessment of haematological response, free(More)
To the Editor—Despite increases in obesity, data to guide dosing of voriconazole in this population are lacking. We describe the dosing of intravenous voriconazole in an obese patient undergoing an allogeneic hematopoeitic cell transplant. A 30-year-old male underwent a matched unrelated donor allogeneic stem cell transplant (SCT) for the treatment of acute(More)
Human metapneumovirus (hMPV) is an emerging human pulmonary pathogen that is genetically related to respiratory syncytial virus. It has been increasingly associated with respiratory illnesses over the last few decades. Immunocompromised patients are particularly susceptible with resultant morbidity and mortality. We describe our experience with 9(More)
The underlying risk of venous thromboembolism (VTE) is unclear in patients undergoing hematopoietic cell transplantation (HCT). As such, these patients should still be considered at risk for development of VTE due to factors such as their underlying malignancy and the marked inflammatory state that develops from treatment. The purpose of this study was to(More)
STUDY OBJECTIVE To evaluate the steady-state pharmacokinetic parameters of standard cefepime dosing regimens in a hematologic malignancy and hematopoietic cell transplant patient population with febrile neutropenia. DESIGN Open-label, single-center, prospective pharmacokinetic study. SETTING National Cancer Institute-designated cancer center. PATIENTS(More)
We compared survival outcomes following myeloablative allotransplant (MAT) or cyclophosphamide/fludarabine (Cy/Flu) nonmyeloablative allotransplant (NMAT) for 165 patients with acute myelogenous leukemia (AML) in remission or without frank relapse. Patients who received NMAT were more likely to be older and have secondary AML and lower performance status.(More)