We present Guru, an intelligent tutoring system for high school biology that has conversations with students, gestures and points to virtual instructional materials, and presents exercises for extended practice. Guru's instructional strategies are modeled after expert tutors and focus on brief interactive lectures followed by rounds of scaffolding as well… (More)
We examined the impact of familial factors on age at onset in schizophrenia. Results from a literature review and from new analyses of two family studies and one twin study of schizophrenia support the following hypotheses: (1) no strong or consistent relationship exists between age at onset in schizophrenia and recurrence risk for schizophrenia in… (More)
Schizophrenics meeting DSM-III criteria were divided, based on family history of affective disorder in first-degree relatives, into three groups: N-schizophrenics, no relative with affective disorder; U-schizophrenics, a relative with unipolar affective disorder; and B-schizophrenics, a relative with bipolar affective disorder. Although N- and… (More)
A patient with complex symptomatology is described. Progress in the diagnosis of sleep disorders gradually led to successful diagnosis-based treatment.
The authors review the evidence indicating that puerperal psychosis is a nosological entity. The psychosis most closely resembling puerperal psychosis is the schizophreniform variant of manic-depression, and the authors propose that if marked differences can be found between that state and puerperal psychosis, then the finding will tend to confirm the… (More)
For the 2003 monkeypox virus (MPXV) outbreak in the United States, interhuman transmission was not documented and all case-patients were near or handled MPXV-infected prairie dogs. We initiated a case-control study to evaluate risk factors for animal-to-human MPXV transmission. Participants completed a questionnaire requesting exposure, clinical, and… (More)
In this preliminary and exploratory study, we collected the dream reports and mood ratings of 6 outpatients with bipolar disorder over a 6-month period to compare the relationship between dream themes and mood states. We found that neutral mood states were associated with mundane, routine or uneventful dreams while manic states featured bizarre and… (More)
To test the hypothesis that mumps occurs less frequently and later in patients with multiple sclerosis, histories were taken from patients and matched controls by a single observer at a university hospital in Canada, and in the course of domiciliary visits in England. 63 consecutive patients with multiple sclerosis in two neurological practices, and 63… (More)