Patrick George

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Most cancer genomes are characterized by the gain or loss of copies of some sequences through deletion, amplification or unbalanced translocations. Delineating and quantifying these changes is important in understanding the initiation and progression of cancer, in identifying novel therapeutic targets, and in the diagnosis and prognosis of individual(More)
Patients who receive curative treatment for lung cancer can develop additional lung tumors that may or may not be related to the original tumor and thus require different clinical management. If a subsequent tumor has a pattern of allele loss, revealed by allelotype analysis, overlapping that of the first tumor, it is believed to be a local recurrence or(More)
Resection of the medial temporal lobes in humans produces an anterograde amnesia in which past memories are seemingly intact, but the ability to form new memories is compromised. Efforts to reproduce these symptoms in animals have relied extensively on the delayed non-match-to-sample (DNMS) and the delayed match-to-sample (DMS) tasks. DNMS deficits have(More)
The introduction of smart cards into trusted architectures establishes a clear-cut separation between the roles and responsibilities of both platform and user. On one hand, the Trusted Platform Module (TPM) ensures the platform trustworthiness and secures platform credentials and secrets, while smart cards guarantee user identity and protect user(More)
Cryodes were implanted over the prelunate and fusiform gyri in 4 monkeys. The intention was to block the prestriate projection to the inferotemporal cortex (IT). Cooling this cortex produced deficits that were completely reversed by removing the cold. The deficits appeared in the recall of visual discriminations that were learned prior to the application of(More)
Two bilateral cooling probes were placed over the parahippocampal gyrus (pg) and the cortex just dorsolateral to it, the posterior inferotemporal gyrus (p.itg) in 4 Macaca fascicularis. Behavioral tests included: delayed match-to-sample (DMS); the acquisition and retention of single visual discriminations; the acquisition and retention of a concurrent(More)
At IECEC 2001, our team presented a paper on the new stretched lens array (SLA), including its evolution from the successful SCARLET array on the NASA/JPL Deep Space 1 spacecraft. Since that conference, the SLA team has made significant advances in the SLA technology, including component-level improvements, array-level optimization, space environment(More)
Telomerase, the enzyme that stabilizes telomere length is reactivated with almost all cancer types, and may be a useful diagnostic marker for malignancy. Telomerase activity has been detected in germ line cells and most cancer cells, whereas most normal somatic cells have no clearly detectable telomerase activity. In our study, we aim to detect telomerase(More)
This experiment employed reversible cold lesions to assess the possible storage functions of inferotemporal cortex (IT) for visual information. Four Macaca fascicularis were chronically implanted with 4 bilateral sets of cryodes which covered dorsal and ventral IT. Animals learned visual discrimination problems while subsections of IT were cooled. Retention(More)