Patrick Galera

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BACKGROUND Desflurane triggers post-conditioning in the diabetic human myocardium. We determined whether protein kinase C (PKC), mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channels, Akt, and glycogen synthase kinase-3β (GSK-3β) were involved in the in vitro desflurane-induced post-conditioning of human myocardium from patients(More)
We study the changes taking place in hyaluronic acid, chondroitin 4-sulfate (C4-S) and condroitin 6-sulfate (C6-S), at ionic strengths of 0.10, 0.15, and 0.20 in NaCl, in a neutralization process in aqueous solution. We apply the equation of Henderson Hasselbalch modified for polyelectrolytes and evaluate the changes in the electrostatic free energy(More)
Since local anaesthetics are known to interact with membrane lipids, we have examined the changes taken place by procaine hydrochloride in lipid matrices as a function of pH. Rheological methods might give useful information on the association of this anaesthetic with soybean lecithin. The procaine interacted with negatively charged phospholipid polar head(More)
BACKGROUND The nuclear factor-κB (NF-κB) pathway is a key mediator of inflammation; however, few studies have examined the direct effects of NF-κB inhibition on the skin. OBJECTIVES To investigate NF-κB activity in cultured human fibroblasts and to investigate the effects of 4-hexyl-1,3-phenylenediol (an NF-κB inhibitor) on elastin and collagen gene(More)
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