Learn More
We present T ALplanner, a forward-chaining planner based on the use of domain-dependent search control knowledge represented as formulas in the Temporal Action Logic TAL. TAL is a narrative based linear metric time logic used for reasoning about action and change in incompletely speciied dynamic environments. TAL is used as the formal semantic basis for(More)
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptor is also required for the above responses. We now report on the cloning and enzymatic characterization of(More)
Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in several aspects in embryonic development and several growth factor signaling cascades. We now report that an inactive phosphorylated pool of the enzyme colocalizes with F-actin in both neuronal and nonneuronal cells. Semaphorin 3A (Sema 3A), a molecule that inhibits(More)
We present a new forward chaining planner, TALplan-ner, based on ideas developed by Bacchus [5] and Ka-banza [11], where domain-dependent search control knowledge represented as temporal formulas is used to effectively control forward chaining. Instead of using a linear modal tense logic as with Bacchus and Kabanza, we use TAL, a narrative-based linear(More)
The subventricular zone (SVZ) is a major site of neurogenesis in the adult. We now show that ependymal and proliferating cells in the adult mouse SVZ express diacylglycerol lipases (DAGLs), enzymes that synthesise a CB1/CB2 cannabinoid receptor ligand. DAGL and CB2 antagonists inhibit the proliferation of cultured neural stem cells, and the proliferation of(More)
Cerebellar neurons, cultured on monolayers of 3T3 fibroblasts or on a polylysine/extracellular matrix-coated substratum, responded to a soluble recombinant L1-Fc chimera by extending longer neurites than controls. The response was inhibited by pretreating neurons with antibodies to L1 or antibodies to the fibroblast growth factor (FGF) receptor. The(More)
In the present study we show that following transfection in 3T3 cells, human Robo1 and Robo2 stimulate neurite outgrowth from Robo-positive neurons (retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (cerebellar granule cells). The neurite outgrowth response was inhibited by an antibody raised against the first Ig domain of(More)