• Publications
  • Influence
Clinical Spectrum of Paradoxical Deterioration During Antituberculosis Therapy in Non-HIV-Infected Patients
  • V. Cheng, P. Ho, +4 authors K. Yuen
  • Medicine
    European Journal of Clinical Microbiology and…
  • 1 November 2002
TLDR
A surge in the lymphocyte count, accompanied by an exaggerated tuberculin skin reaction, was observed in the authors' patients during the paradoxical deterioration, analogous to the findings in HIV-positive patients.
Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection
TLDR
The findings that horseshoe bats are the natural reservoir for SARS-CoV-like virus and that civets are the amplification host highlight the importance of wildlife and biosecurity in farms and wet markets, which can serve as the source and amplification centers for emerging infections.
Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong
TLDR
In this 12-month prospective study, nasopharyngeal aspirates from patients with acute respiratory tract infections were subjected to reverse transcription-PCRs specific for CoV-HKU1 and human coronaviruses NL63, OC43, and 229E, and upper respiratory infection was the most common presentation.
Bacteremia caused by staphylococci with inducible vancomycin heteroresistance.
TLDR
The clinical significance of bacteremia due to vancomycin-heteroresistant staphylococci and a rapid laboratory screening method were examined andIndiscriminate sequential use of beta-lactams and glycopeptides may facilitate the emergence of glycopePTide resistance.
Risk Factors for Development of Paradoxical Response During Antituberculosis Therapy in HIV-Negative Patients
  • V. Cheng, W. Yam, +5 authors K. Yuen
  • Medicine
    European Journal of Clinical Microbiology and…
  • 24 September 2003
TLDR
Patients with paradoxical response were more likely to have extrapulmonary involvement, and to have lower baseline lymphocyte counts, than patients without clinical deterioration after antituberculosis therapy (control group), which would be useful in understanding the exact immunological mechanisms involved in immunorestitution.
Invasive Streptococcus iniae Infections Outside North America
TLDR
The first two cases of invasive S. iniae infections in two Chinese patients outside North America are reported, and the distinct genetic profile described previously in clinical isolates from Canada are found to be genetically unrelated.
Laribacterhongkongensis gen. nov., sp. nov., a Novel Gram-Negative Bacterium Isolated from a Cirrhotic Patient with Bacteremia and Empyema
ABSTRACT A bacterium was isolated from the blood and empyema of a cirrhotic patient. The cells were facultatively anaerobic, nonsporulating, gram-negative, seagull shaped or spiral rods. The
Eggerthella hongkongensis sp. nov. and eggerthella sinensis sp. nov., two novel Eggerthella species, account for half of the cases of Eggerthella bacteremia.
TLDR
It is suggested that Eggerthella bacteremia is much more common than expected and is associated with significant morbidity and mortality and the 2 novel species account for half of the cases.
Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC/2012: Implications for Disease Pathogenesis and Clinical Manifestation
TLDR
A cell line susceptibility study with 28 cell lines found that HCoV-EMC can infect primate, porcine, and bat cells and therefore may jump interspecies barriers and can also infect civet lung fibroblast and rabbit kidney cell lines.
Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests
TLDR
A seroprevalence study on archived sera from 94 game-food animal handlers at a wild life market, 28 SARS patients, and 152 healthy blood donors in Southern China to assess the zoonotic potential and evidence for intrusion of HCoV-EMC and related viruses into humans found a significant B-cell epitope overlapping the heptad repeat-2 region of Spike protein.
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