Patrick C. Choy

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Hyperhomocysteinemia is an independent risk factor for cardiovascular disorders. Elevated plasma homocysteine (Hcy) concentration is associated with other cardiovascular risk factors. We previously reported that Hcy stimulated cholesterol biosynthesis in HepG2 cells. In the present study, we investigated the underlying mechanisms of Hcy-induced hepatic(More)
Diabetic nephropathy is one of the most significant microvascular complications in patients with type 2 diabetics. The concise mechanism of diabetic nephropathy is unknown and there is no successful treatment. The objective of study was to investigate effects of Chinese herbs (Tangshen Formula) on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty(More)
  • Hong Shen, Guojiang Huang, +5 authors Yuewen Gong
  • 2003
Smads are intracellular signaling molecules of the transforming growth factor-beta (TGF-beta) superfamily that play an important role in the activation of hepatic stellate cells (HSCs) and hepatic fibrosis. Excepting the regulation of Smad7, receptor-regulated Smad gene expression is still unclear. We employed rat HSCs to investigate the expression and(More)
The role of peroxisome proliferator-activated receptor ␣ (PPAR ␣)-stimulated phospholipase A 2 (PLA 2) in cardiac mitochondrial cardiolipin (CL) biosynthesis was examined in both in vivo and in vitro models. Treatment of rat heart H9c2 cells with clofibrate increased the expression and activity of 14 kDa PLA 2 but did not affect the pool size of CL.(More)
REVIEW ARTICLE Assembly and secretion of hepatic very-low-density lipoprotein RESEARCH PAPERS Proteins Neoantigens in complement component C3 as detected by mono-clonal antibodies. Mapping of the recognized epitopes by synthetic peptides Myelin basic protein is affected by reduced synthesis of myelin proteolipid protein in the jimpy mouse Botulinum type F(More)
Cytosolic phospholipase A 2 (cPLA 2) is responsible for the release of arachidonic acid, a precursor for eicosanoid biosynthesis, from cellular phospholipids. The objective of this study is to examine the regulation of cPLA 2 by peroxisome proliferator-activated receptor (PPAR) activators in preadipo-cyte SW872 (SW) cells. PPAR belong to the superfamily of(More)
Within the group of botanical products there is a large range of variation with regard to their properties. Some products are identical to foods while others come close to or are medicines. Botanical products are regulated differently within the different member states of the European Union (EU) and globally. They are regulated either as food or as(More)
Cardiolipin (CL) is a mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes involved in the generation of ATP. In order to facilitate its role CL must be remodeled with appropriate fatty acids. We previously identified a human monolysocardiolipin acyltransferase activity which remodels(More)
The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated. In this study, lipid biosynthesis in myoblasts and hepatocytes was reassessed by conducting pulse-chase experiments with(More)
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