Patrick Braun

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a-Synuclein (as) is a 140-residue protein abundantly present in the Lewy bodies characteristic of Parkinson's disease.[1-31 It is a member of the class of intrinsically disordered proteins (lOPs) that have unusual properties and whose physiological relevance is becoming increasingly recognized.[41 lOPs lack a well-defined three-dimensional fold and display(More)
The interaction of multivalent carbohydrate derivatives with carbohydrate-binding proteins (lectins) is frequently observed in biological systems, and th e ir inhibition by tailored multivalent ligands is a powerful strategy for the treatment of many human diseases. fli Compared to monovalent interactions , multivalency can lead to significantly increased(More)
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