Patrick Becker

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To understand the impact of ionizing irradiation from diagnostics and radiotherapy on cells, we examined K+ channel activity before and immediately after exposing cells to X-rays. Already, low dose in the cGy range caused in adenocarcinoma A549 cells within minutes a hyperpolarization following activation of the human intermediate-conductance Ca2+-activated(More)
Prof. Slusallek for providing the topic for this advanced pratical project. Marco Lohse for his supervision. Andreas Pomi for his technical advices and for implementing most of the LCD driver. Georg Demme for designing graphics for the MMBox-Application. Disclaimer The software described in this document is under continuous development. Some concepts and(More)
Ionizing radiation is a universal tool in tumor therapy but may also cause secondary cancers or cell invasiveness. These negative side effects could be causally related to the human-intermediate-conductance Ca2+-activated-K+-channel (hIK), which is activated by X-ray irradiation and affects cell proliferation and migration. To analyze the signaling cascade(More)
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