Patrick A. Lasala

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The authors present a rare case of lipoma of the sylvian fissure found in a 34-year-old man who presented with seizures. The patient underwent craniotomy and an attempted resection of the lesion, which was initially believed to be a dermoid tumor. The imaging characteristics of dermoids and lipomas are extremely similar. Given the difference in the natural(More)
Glioblastoma multiforme (GBM) is a highly lethal brain cancer. Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture. However, their mechanisms of action may vary, as demonstrated by(More)
Patients with epilepsia partialis continua may develop progressive neurological deficits of unclear origin. It is possible that repetitive epileptic spikes induce plastic changes in the cortex analogous to the changes observed following direct microstimulation. A child is reported with focal cortical dysplasia, intractable focal seizures, worsening(More)
Meningeal melanocytoma is a rare pigmented tumor originating from the melanocytes that generally occurs in the posterior fossa and the spinal cord. Although it is known as a relatively benign tumor, some recurrences have been reported. We report two cases of spinal meningeal melanocytoma with immunohistochemical and ultrastructural studies. In addition, we(More)
OBJECTIVE To describe the neuropathologic findings and clinical course of 2 patients who underwent temporal lobectomy for medically refractive epilepsy and were later found to have high anti-glutamic acid decarboxylase (GAD) concentrations. METHODS Small case series. RESULTS Neuropathologic examination of both patients revealed International League(More)
Pituitary apoplexy is an uncommon phenomenon typically characterized by vascular insufficiency or acute hemorrhage into a pituitary adenoma. The overall incidence of pituitary apoplexy ranges between 1 and 25% of all pituitary adenomas. With the widespread use of MRI technology, the diagnosis of asymptomatic intratumoral hemorrhage is closer to 10%. The(More)
Proprioceptive loss, paresthesias, and atrophy of the hands can occur with disorders afflicting the upper cervical spinal cord. The diagnosis might be erroneous, because compression in this region might produce signs and symptoms that seem to originate in the lower cervical cord. This article reviews the clinical presentation and radiographic data of a(More)
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