Patricia T. Fletcher

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This paper introduces a regression method for modeling the relationship between a manifold-valued random variable and a real-valued independent parameter. The principle is to fit a geodesic curve, param-eterized by the independent parameter, that best fits the data. Error in the model is evaluated as the sum-of-squared geodesic distances from the model to(More)
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG-PET) thus far rarely has been used to advance the development of new treatments for Alzheimer's disease (AD). Now that FDG-PET with standard acquisition protocols for dementia is widely available, change in cerebral glucose metabolism is a feasible outcome variable for clinical drug trials.(More)
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