New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme… (More)
INTRODUCTION Orthopaedic oncology researchers face several obstacles in the design and execution of randomised controlled trials, including finite fiscal resources to support the rising costs of clinical research and insufficient patient volume at individual sites. As a result, high-quality research to guide clinical practice has lagged behind other… (More)
" Cyanobacteria gene and protein sequences in diurnal oscillation metabolic processes, " Proc SPIE 7819, art. no. 78190U (2010). " Cyanobacteria gene and protein sequences in diurnal oscillation metabolic processes, " Proc SPIE 7819, art. no. 78190U (2010).