Patricia Mousmanis

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OBJECTIVE To examine the risk for persistent pulmonary hypertension of the newborn associated with antenatal exposure to antidepressants. DESIGN Systematic review and meta-analysis. DATA SOURCES Embase, Medline, PsycINFO, and CINAHL from inception to 30 December 2012. ELIGIBILITY English language studies reporting persistent pulmonary hypertension of(More)
IMPORTANCE Untreated depression during pregnancy has been associated with increased morbidity and mortality for both mother and child and, as such, optimal treatment strategies are required for this population. CONTEXT There are conflicting data regarding potential risks of prenatal antidepressant treatment. OBJECTIVE To determine whether prenatal(More)
OBJECTIVE Depression often remains undertreated during pregnancy and there is growing evidence that untoward perinatal outcomes can result. Our systematic review and meta-analysis was conducted to determine whether maternal depression during pregnancy is associated with adverse perinatal and infant outcomes. DATA SOURCES MEDLINE, EMBASE, CINAHL, and(More)
OBJECTIVE Depression is often not optimally treated during pregnancy, partially because of conflicting data regarding antidepressant medication risk. This meta-analysis was conducted to determine whether antenatal antidepressant exposure is associated with congenital malformations and to assess the effect of known methodological limitations. DATA SOURCES(More)
OBJECTIVE Conflicting reports on potential risks of antidepressant exposure during gestation for the infant have been reported in the literature. This systematic review and meta-analysis on immediate neonatal outcomes were conducted to clarify what, if any, risks are faced by infants exposed to antidepressants in utero. Subanalyses address known(More)
Needle fear typically begins in childhood and represents an important health-related issue across the lifespan. Individuals who are highly fearful of needles frequently avoid health care. Although guidance exists for managing needle pain and fear during procedures, the most highly fearful may refuse or abstain from such procedures. The purpose of a clinical(More)
In perinatal psychiatry, randomized controlled trials are often not feasible on ethical grounds. Many studies are observational in nature, while others employ large databases not designed primarily for research purposes. Quality assessment of the resulting research is complicated by a lack of standardized tools specifically for this purpose. The aim of this(More)
A guide to Advanced Maternal Age for Ontario service providers, including a summary of statistical trends, influencing factors, health benefits, health risks and recommendations for care. Best Start is grateful to the following people for sharing their expertise as advisors, key informants and expert reviewers in the development of this manual: Best Start(More)
Executive Summary Early childhood or " the early years " is the most important developmental phase of life in which crucial advancements in physical, social, cognitive, emotional and language domains take place. Experiences during this time-and even before birth-influence health, education and economic prospects throughout life. Experiences in the first six(More)
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