Patricia M. Mertz

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The medical literature describes numerous in vitro and in vivo wound-healing models. The selection of an animal model depends on a number of factors including availability, cost, ease of handling, investigator familiarity, and anatomical/functional similarity to humans. Small mammals are frequently used for wound healing studies, however, these mammals(More)
A biofilm is a collection of microbial cells that are attached to a surface and embedded in a self-produced extrapolymeric substance. The understanding of the biofilm phenotype is important in the understanding of bacteria in vitro but it has been difficult to translate biofilm science to the clinical setting. More recently, preliminary criteria for(More)
We studied the effects of direct electric current supplied by an energized silver-coated electrode on dermal and epidermal wound healing. Keratome-induced wounds (0.3 mm deep) on the skin of young domestic pigs were treated with either an energized (50-300 microA) electrode (DC), an unenergized electrode (placebo), or left untreated. Wounds were excised on(More)
BACKGROUND Many bacteria have become resistant to commonly-used antibiotics. OBJECTIVE The purpose of this study was to examine the effect of a cadexomer iodine wound dressing on methicillin resistant Staphylococcus aureus (MRSA). METHOD Partial thickness wounds were made on the backs of three pigs and inoculated with a known amount of MRSA. Wounds were(More)
Previous in vitro studies suggest that the interleukin-1 (IL-1) proteins may be important for skin function. Keratinocytes are known to synthesize IL-1 in response to injury and IL-1 has been shown to stimulate fibroblast and keratinocyte growth, collagen synthesis by fibroblasts, and chemotaxis of keratinocytes. In order to evaluate the ability of IL-1 to(More)
BACKGROUND In chronic wounds, biofilms probably play a vital role in protecting bacteria from host defenses and antimicrobial medications by creating a barrier of exopolysaccharide that is difficult for the immune system and antibiotics to penetrate. A biofilm consists of an exopolysaccharide matrix that is produced and secreted by certain species of(More)
The purpose of this study was to examine the rate of epithelization of second-degree burn wounds with use of two debridement times (early versus late). Burn wounds were randomly assigned to one of the following treatment groups: (1) control, no debridement, (2) early debridement at 24 hours after burning, or (3) late debridement at 96 hours after burning.(More)
OBJECTIVES To evaluate Staphylococcus aureus isolates from infected skin lesions for their potential to produce immune system-modulating toxins and to correlate these with white blood cell (WBC) counts associated with these lesions. DESIGN Specimens were obtained for bacterial culture and gram staining from 105 infected skin lesions, and the number of(More)
We examined experimentally the relationship between perpendicular and tangential electrical conductivities, sigma, and peak current density J, in pig skin dermis and subcutaneous fat specimens by using a four-electrode measuring system with rectangular pulse electrical current (RPEC). We also investigated the relationship of the conductivity, sigma, vs.(More)
Epithelialization of second-degree burn wounds is known to be accelerated by topical treatment with hydrogel dressings and further enhanced by pulsed electrical stimulation compared with no treatment (air exposure). Tissue collagenase has been proposed to be involved during the process of epithelialization. In the present study collagenase levels were(More)