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OBJECTIVE Differences in diagnostic criteria and methods have led to mixed results regarding the metabolite pattern of HIV-associated brain injury in relation to neurocognitive impairment. Therefore, a multicenter MRS consortium was formed to evaluate the neurometabolites in HIV patients with or without cognitive impairment. METHODS Proton magnetic(More)
We have examined recovery from the acute effects of unilateral and bilateral visual cortex lesions on horizontal optokinetic nystagmus (OKN) in the cat. A single bilateral cortical lesion virtually abolishes monocular OKN in response to temporalward stimulation, and severely reduces OKN in response to nasalward stimulation at higher drum velocities. A(More)
To gauge the strength by which the testes influence stress-induced activation of neurosecretory neurons in the paraventricular nucleus, we studied within medial parvocellular neurons the effects of gonadectomy on restraint-induced Fos-immunoreactivity and on CRH and arginine vasopressin (AVP) heteronuclear (hn) RNA expression levels. Relative to intact male(More)
PURPOSE To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). MATERIALS AND(More)
The purpose of our study was to demonstrate the feasibility of using in vivo proton Magnetic Resonance Spectroscopy (MRS) to monitor the brain manifestations of SIV infection in the macaque model of AIDS. Previous spectroscopy work on macaque brain tissue and in vivo work in humans is reviewed to provide the motivation and context for this study. We(More)
A novel method of chemical shift imaging utilizing echoplanar imaging (EPI) has been developed for the purpose of improving the spatial resolution of metabolite images for the specific goal of high spatial resolution mapping of neuronal content. An EPI sequence was modified to allow temporal offsets of the 180 degree refocusing pulse that encode the(More)
Dendritic pathology associated with traumatic brain injury may be identified by microtubule associated protein-2 (MAP-2) immunohistochemistry. The aim of this study was to examine the dendritic response in the cerebral cortical mantle in an ovine head impact model using MAP-2 immunostaining as a marker for dendritic injury. The loss of cortical MAP-2(More)
PURPOSE To define radiographic dose-response relationships for proton radiosurgery using a rat brain model. METHODS AND MATERIALS A group of 23 rats was treated with Bragg peak proton beam irradiation involving the right hippocampus. Single doses of 5, 12, 20, 30, 60, 90 and 130 cobalt gray equivalents (CGE) were delivered to groups of 3 animals using(More)
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