Patricia L. Weigel Green

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IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression is poorly understood, but previous findings have suggested that physical interactions with T cells may play a role. This report investigates signalling mechanisms involved in the production of(More)
We and others have reported that rheumatoid arthritis (RA) synovial T cells can activate human monocytes/macrophages in a contact-dependent manner to induce the expression of inflammatory cytokines, including tumour necrosis factor alpha (TNFalpha). In the present study we demonstrate that RA synovial T cells without further activation can also induce(More)
BACKGROUND Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in a cytokine cocktail acquired effector function for contact-dependent induction of proinflammatory cytokines from monocytes. We termed these cells cytokine-activated (Tck) cells and found that the signalling pathways elicited in the responding(More)
The goal of the current article is to present the results of a randomized pilot investigation of a brief dynamic psychotherapy compared with treatment-as-usual (TAU) in the treatment of moderate-to-severe depression in the community mental health system. Forty patients seeking services for moderate-to-severe depression in the community mental health system(More)
INTRODUCTION Knowledge is everywhere. While most would argue this is of benefit, this fact poses a new challenge. How do we determine what is of value; that is, what knowledge should be collected, utilized and retained, versus what should be ignored or discarded? Our study focuses on the identification of individual Knowledge Management practices of(More)
Background. Acute bronchiolitis infection during infancy is associated with an increased risk of asthma later in life. The objective of this study was to determine if inhaled steroids are effective in preventing the development of recurrent wheeze or asthma following acute bronchiolitis. Methods. Multiple databases and bibliographies of selected references(More)
Although strong binding interactions between protein receptor and ligand do not require the participation of a large number of amino acids in either site, short peptide chains are generally poor at recreating the types of protein-protein interactions which take place during cell recognition and signalling process, probably because their flexible backbones(More)
  • WRITTEN BY, Aria S. Sasser, +11 authors Elizabeth Yakubu
  • 2000
• Florida REACH is deeply committed to eliminating the racial disparity between African American and White infant mortality rates. • Florida REACH believes that all infants deserve the same opportunities to live and thrive, to be born free from infections and impairments, and to live long, healthy lives. • Florida REACH is a community-driven process and(More)
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