Patricia L Blanchette

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BACKGROUND Constipation is frequent in PD, although its onset in relation to clinical PD has not been well described. Demonstration that constipation can precede clinical PD could provide important clues to understanding disease progression and etiology. The purpose of this report is to examine the association between the frequency of bowel movements and(More)
OBJECTIVE To assess the relationship between impaired glucose tolerance and both vascular dementia and AD. BACKGROUND Diabetes and abnormalities of glucose metabolism have been associated with stroke and poor cognitive function. In addition, glycoproteins and glycosylation have been postulated to be associated with the development of neuritic plaques(More)
CONTEXT Parkinson disease (PD) has an unknown cause; however, convincing evidence is emerging that indicates pesticides can selectively injure the dopaminergic system in laboratory animals. Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD. OBJECTIVE To determine whether working on a plantation in(More)
OBJECTIVE To examine the relation between milk and calcium intake in midlife and the risk of Parkinson disease (PD). METHODS Findings are based on dietary intake observed from 1965 to 1968 in 7,504 men ages 45 to 68 in the Honolulu Heart Program. Men were followed for 30 years for incident PD. RESULTS In the course of follow-up, 128 developed PD(More)
BACKGROUND Evidence suggests that nigrostriatal system disorders are associated with PD and adiposity. Whether patterns of adiposity coexist or predate clinical PD is unknown. This report examines the relation between midlife adiposity and the risk of PD. METHODS Measurement of adiposity occurred from 1965 to 1968 in 7,990 men in the Honolulu Heart(More)
BACKGROUND The Honolulu Heart Program (HHP) is a prospective study of heart disease and stroke that has accumulated risk factor data on a cohort of 8,006 Japanese American men since the study began in 1965. A recent examination of the cohort identified all patients with vascular dementia (VaD) using the criteria of the California Alzheimer's Disease(More)
BACKGROUND The purpose of this prospective study was to examine whether fibrinogen level is associated with Parkinson disease (PD) for both prevalent and incident cases. METHODS The Honolulu Asia-Aging Study is a longitudinal study of Japanese-American men based on the Honolulu Heart Study birth cohort. The original cohort consisted of 8,006 participants(More)
This bibliography identifies items of interest to those working with Alzheimer's disease in Hispanic/Latino American communities. The list is not exhaustive and selection does not constitute endorsement. It includes items on research outside the United States because of possible application to Hispanic/Latino groups in America. Additional items are listed(More)
This study assessed the clinical utility of repeating the phrase "No ifs, ands, or buts" for cognitive testing in Hawaii. 242 subjects were screened; 25 (10%) had cognitive impairment. 68% of all subjects were unable to say the phrase "No ifs, ands, or buts" (83% of cognitively impaired and 67% of cognitively intact, p = 0.122). Specificity for cognitive(More)
OBJECTIVE To determine diagnostic accuracy for AD in a population-based study of Japanese-American men. AD is neuropathologically confirmed for more than 80% of cases at major referral centers (primarily Caucasians); however, information on diagnostic accuracy in population-based studies and studies of different ethnic groups is limited. METHODS There(More)