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Upregulation of xCT, the inducible subunit of a membrane-bound amino acid transporter, replenishes intracellular glutathione stores to maintain cell viability in an environment of oxidative stress. xCT also serves as a fusion-entry receptor for the Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of Kaposi's sarcoma (KS). Ongoing KSHV(More)
Traditional collaborative filtering generates recommendations for the active user based solely on ratings of items by other users. However, most businesses today have item ontologies that provide a useful source of content descriptors that can be used to enhance the quality of recommendations generated. In this article, we present a novel approach to(More)
Macrophages are an important source of inflammatory cytokines generated during the innate immune response,but in the microenvironment of certain tumors,macrophages promote tumor progression through their preferential secretion of cytokines that support tumor cell growth and suppress antitumoral immune responses. KSHV is the causative agent of KS and(More)
In this paper we report on a pilot user study aimed at evaluating two aspects of recommender systems that have not been the aim of previous user studies in the field. Firstly, item semantics may be incorporated into a collaborative recommender system and we wish to measure the effect on user satisfaction. Secondly, we would like to evaluate different(More)
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