Patricia K Welch

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CC chemokine receptor (CCR) 3 is a chemokine receptor implicated in recruiting cells, particularly eosinophils (EPhi), to the lung in episodes of allergic asthma. To investigate the efficacy of selective, small molecule antagonists of CCR3, we developed a murine model of EPhi recruitment to the lung. Murine eotaxin was delivered intranasally to mice that(More)
A series of 2'-substituted chalcone derivatives has been found to show potent inhibition of the production of IL-1 beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS), with IC50 values in the 0.2-5.0-microM range. Some members of the series have also shown inhibition of septic shock induced in mice by injection of LPS,(More)
We analyzed the energy-, nutrient- and food-intake patterns of pregnant adolescents before and during participation in a supplemental-food program. The dietary data on the pregnant adolescents were compared to those on older pregnant women and non-pregnant adolescents. Weight gain per trimester, hemoglobin and hematocrit values were reported. In general,(More)
In brief: This study examined the effects of nutrition education (through individual counseling) on the body composition and diet patterns of 39 female college athletes. Anthropometric and diet data were collected before and after the playing season. Ten of the athletes received individual nutrition counseling during the season and comprised group 1; the(More)
This study assessed the change in nutritional intake and status of 15 nursing home residents receiving a pureed diet along with commercial supplements over a 6 month period. The nutritional supplements were well accepted with a significant increase in the energy and nutrient intake after their addition. Gastrointestinal distress was measured by stool size(More)
The discovery of novel and selective small molecule antagonists of the CC Chemokine Receptor-3 (CCR3) is presented. Simple conversion from a 4- to 3-benzylpiperidine gave improved selectivity for CCR3 over the serotonin 5HT(2A) receptor. Chiral resolution and exploration of mono- and disubstitution of the N-propylurea resulted in several 3-benzylpiperidine(More)
Starting with our previously described(20) class of CC chemokine receptor-3 (CCR3) antagonist, we improved the potency by replacing the phenyl linker of 1 with a cyclohexyl linker and by replacing the 4-benzylpiperidine with a 3-benzylpiperidine. The resulting compound, 32, is a potent and selective antagonist of CCR3. SAR studies showed that the(More)
Although there has been an increase in pregnancy in women over 35 years of age, the literature contains no information on dietary intakes of older pregnant women. Several studies have reported the nutritional status of pregnant adolescents who are considered to be at nutritional risk. This study investigated the energy, nutrient, and food intake patterns of(More)
This study reported on the dietary intake of the institutionalized diabetics consuming low-kilocalorie sweeteners or fructose. The dietary intake was comparable to that for nondiabetics and consistent with the data from NHANES II. Nutrient intakes for diabetics met 100% of the RDA when either sweetener was used. Because of the increase in carbohydrates from(More)