Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

• Patricia J. Sime, Zhou Xing, F L Graham, Karl G. Csaky, Jack Gauldie
• The Journal of clinical investigation
• 1997

Transforming growth factor (TGF)-beta1 has been implicated in the pathogenesis of fibrosis based upon its matrix-inducing effects on stromal cells in vitro, and studies demonstrating increased… (More)

Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung.

• Martin Kolb, Peter J Margetts, Patricia J. Sime, Jack Gauldie
• American journal of physiology. Lung cellular and…
• 2001

Transforming growth factor (TGF)-beta is a key cytokine in the pathogenesis of pulmonary fibrosis, and pharmacological interference with TGF-beta can ameliorate the fibrotic tissue response. The… (More)

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

• Heather E. Ferguson, Ajit L. Kulkarni, +5 authors Patricia J. Sime
• American journal of respiratory cell and…
• 2009

Pulmonary fibrosis is a progressive scarring disease with no effective treatment. Transforming growth factor (TGF)-beta is up-regulated in fibrotic diseases, where it stimulates differentiation of… (More)

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

• Heather A. Burgess, Louis Eugene Daugherty, +5 authors Patricia J. Sime
• American journal of physiology. Lung cellular and…
• 2005

Pulmonary fibrosis is a progressive life-threatening disease for which no effective therapy exists. Myofibroblasts are one of the key effector cells in pulmonary fibrosis and are the primary source… (More)

Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.

• Christine A Martey, Stephen J. Pollock, +4 authors Patricia J. Sime
• American journal of physiology. Lung cellular and…
• 2004

Cigarette smoking can lead to many human pathologies including cardiovascular and respiratory disease. Recent studies have defined a role for fibroblasts in the development of colon cancer. Moreover,… (More)

TGF-beta, Smad3 and the process of progressive fibrosis.

• Jack Gauldie, Philippe Bonniaud, Patricia J. Sime, Kjetil Ask, Martin Kolb
• Biochemical Society transactions
• 2007

Transient adenovirus-mediated gene transfer of active TGF-beta1 (transforming growth factor-beta1) induces severe and progressive fibrosis in rodent lung without apparent inflammation. Alternatively,… (More)

Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.

• Patricia J. Sime, Katherine M.A. O'Reilly
• Clinical immunology
• 2001

Tissue fibrosis can lead to significant organ dysfunction and resulting patient morbidity and mortality. Unfortunately, the therapeutic repertoire is currently limited, nonspecific, and largely… (More)

A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

• Jack Gauldie, Martin Kolb, Patricia J. Sime
• Respiratory research
• 2002

A recent review article suggested that idiopathic pulmonary fibrosis (IPF) is a disease that is associated more with abnormal wound healing than with inflammation. Data derived from transgenic and… (More)

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

• Hsi-Min Hsiao, Ramil E. Sapinoro, +8 authors Patricia J. Sime
• PloS one
• 2013

INTRODUCTION Cigarette smoke is a profound pro-inflammatory stimulus that contributes to acute lung injuries and to chronic lung disease including COPD (emphysema and chronic bronchitis). Until… (More)

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

• Thomas H Thatcher, Sanjay B. Maggirwar, +4 authors Patricia J. Sime
• The American journal of pathology
• 2007

The transcription factor aryl hydrocarbon receptor (AhR) plays an important role in the response to environmental pollutants. However, its role in normal physiology is unclear. To investigate the… (More)

• ‹
• 1
• 2
• 3
• 4
• 5
• ›