Patricia Huygens

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The immediate posttrial injection of oxotremorine (0.125, 0.250 and 0.500 μMol/kg i.p.) and equimolecular doses of physostigmine can facilitate the retention of a passive avoidance response in mice. Injections given 10 min after training also significantly facilitate retention, but injections given 30 or 120 min after training do not affect retention. These(More)
Hemopoietic cells, the extracellular matrix, growth factors and the microenvironment are involved in the regulation of hemopoiesis. Although the regulation of erythropoiesis is well understood at the cellular level in vivo and in vitro, the role of hemopoietic sites of erythroid progenitors production has not been well defined in both steady state(More)
During the past five years, researchers from the Medical Research Council and Uganda Virus Research Institute (MRC/UVRI) Programme on AIDS have studied sexual behaviour to better understand the risk and the spread of HIV infection in a rural Ugandan community. This paper aims at a reflective critique of the application of various methods of studying sexual(More)
OBJECTIVES This study compares the effects of feeding growing rats with increasing concentrations of casein (C) and wheat gluten (G), proteins that show different biological qualities, on the morphometrical and biomechanical properties of the femoral diaphysis. MATERIALS AND METHODS Female rats were fed with one of ten diets containing different(More)
Naloxone (0.01-1.00 mg/kg, ip) facilitated retention of a one-trial inhibitory avoidance task, when administered to male Rockland mice immediately after training, as indicated by performance on a retention test 48 hr later. The dose-response curve was an inverted U in this range of dose. In these conditions naloxone did not lengthen latencies to(More)
The immediate post-trial injection of the centrally active muscarinic agonist oxotremorine (0.025, 0.050 and 0.100 mg/kg, IP) can facilitate the retention of a passiveavoidance response in mice, as indicated by performance on a retention test 24 h later. Injections given 10 min after training also significantly facilitated retention, but given 120 min after(More)
The immediate posttrial injection of oxotremorine (0.250 μMol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (α-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 μg, 10 μl, 60 min before trial), the immediate posttrial(More)
Arginine stimulates lymphocyte function and is degraded by arginase, an enzyme that is abundantly present in red blood cells. Arginase impairs lymphocyte function and responses in vitro. Leakage of arginase from stored red blood cells may be involved in the lymphocyte dysfunction associated in allogenic blood transfusion. In the present study, arginase(More)
Hypoxia leads to an increase in erythropoiesis, which induces hypertrophy of the erythropoietic marrow and may induce bone resorption. This study investigates the effect of chronic hypobaric hypoxia (simulated high altitude, SHA) on the biomechanics of rat femurs by mechanical tests of diaphyseal stiffness and strength and calculation of some indicators of(More)
Adenohypophyseal hormones are important for normal growth and maintenance of skeletal mass. From a mechanical point of view, the skeleton can be viewed as a biomechanically regulated structure, the strength of which depends on the intrinsic stiffness (material properties) and the spatial distribution (architectural properties) of the mineralized tissue.(More)