Patricia Hess

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The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Unlike CD4(+) T cells, the absence of JNK2 causes increased interleukin(More)
Sixty % of clones isolated from HeLa cells treated with toxic concen trations of a methylating carcinogen showed increased resistance to the cytotoxicity of A'-methyl-A'-nitrosourea. D,7 values were 6-to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme 06-methylguanine-DNA methyltransferase(More)
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