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The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Unlike CD4(+) T cells, the absence of JNK2 causes increased interleukin(More)
Sixty % of clones isolated from HeLa cells treated with toxic concen trations of a methylating carcinogen showed increased resistance to the cytotoxicity of A'-methyl-A'-nitrosourea. D,7 values were 6-to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme 06-methylguanine-DNA methyltransferase(More)
even when did not believe in myself and my family for an upbringing that encouraged me to follow my dreams and whose constant support helped me achieve this goal. ACKNOWLEDGMENTS I gratefully thank Bob Lahue for being all the things that a mentor should be: a knowledgeable and talented scientist, a patient and caring teacher and, when he needed to be, an(More)
determination of liver specific antigens in the urine of rats with toxic necrosis. Prevention of myocardial damage by very early treatment with intravenous streptokinase. New Engl. following reperfusion with streptokinase (Bezold-Jarisch reflex)-a sign of coronary thrombolysis and myocardial salvage. Gotsman MS. Importance of early initiation of intravenous(More)
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