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Interleukin-1 beta in coronary arteries of patients with ischemic heart disease.
- J. Galea, J. Armstrong, P. Gadsdon, H. Holden, S. Francis, C. Holt
- Arteriosclerosis, thrombosis, and vascular…
Interleukin-1 beta (IL-1 beta) is known to have a number of effects on the different cell types present within coronary arteries. In this study we identified the location and phenotype of cells… Expand
Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath.
OBJECTIVES The development of neointimal hyperplasia with subsequent atherosclerotic deposition has been proposed to cause most late vein graft failures. Our unit has previously demonstrated that… Expand
A bioabsorbable (polyglactin), nonrestrictive, external sheath inhibits porcine saphenous vein graft thickening.
- J. Jeremy, R. Bulbulia, +5 authors G. Angelini
- The Journal of thoracic and cardiovascular…
- 1 June 2004
OBJECTIVE External, nonrestrictive, macro-porous polyester stents prevent neointima formation in porcine vein grafts and have been proposed as a therapeutic approach to the prevention of late vein… Expand
Macro-porosity is necessary for the reduction of neointimal and medial thickening by external stenting of porcine saphenous vein bypass grafts.
BACKGROUND placing external non-restrictive macro-porous stents around porcine vein grafts prevents neointima formation and medial thickening in both the short and long term. Whether the porosity of… Expand
Thapsigargin inhibits angiogenesis in the rat isolated aorta: studies on the role of intracellular calcium pools.
- N. Shukla, N. Freeman, P. Gadsdon, G. Angelini, J. Jeremy
- Medicine, Biology
- Cardiovascular research
- 16 February 2001
OBJECTIVE Since the role of Ca2+ in angiogenesis is not fully understood, we investigated the effect of thapsigargin (TG: depletes intracellular Ca2+ pools) and other Ca2+ modulators [ionomycin,… Expand