3'2b transgenic mice have a severe B cell defect, apparently caused by strong feedback inhibition of endogenous H-gene rearrangement coupled with an inability of 3,2b to provide the survival/matu-ration functions of/~. A unique 3,2b transgenic line, named the C line, was found to permit B cell development. When the C line is crossed with a #-membrane… (More)
A new T-cell receptor alpha-chain-like molecule has been identified in precursor T cells. This protein may be part of a receptor complex that induces T-cell maturation.